HCSGD entry for CEACAM1
1. General information
| Official gene symbol | CEACAM1 |
|---|---|
| Entrez ID | 634 |
| Gene full name | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) |
| Other gene symbols | BGP BGP1 BGPI |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001525 | Angiogenesis | NAS | biological_process |
| GO:0003674 | Molecular_function | ND | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | NAS | cellular_component |
| GO:0007156 | Homophilic cell adhesion | NAS | biological_process |
| GO:0007229 | Integrin-mediated signaling pathway | NAS | biological_process |
| GO:0016020 | Membrane | TAS | cellular_component |
| GO:0016021 | Integral component of membrane | IDA | cellular_component |
| GO:0016477 | Cell migration | NAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0695291288 | 0.9631154059 | 0.5643158187 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0853136991 |
| GSE13712_SHEAR | Up | 2.8093562614 |
| GSE13712_STATIC | Up | 1.4655644138 |
| GSE19018 | Up | 0.0790942176 |
| GSE19899_A1 | Up | 0.1024137824 |
| GSE19899_A2 | Up | 0.0971015979 |
| PubMed_21979375_A1 | Up | 0.2495437612 |
| PubMed_21979375_A2 | Down | -0.0477992376 |
| GSE35957 | Up | 0.0738907466 |
| GSE36640 | Down | -0.0102893838 |
| GSE54402 | Up | 0.0343431146 |
| GSE9593 | Up | 0.0639262801 |
| GSE43922 | Up | 0.0133824986 |
| GSE24585 | Up | 0.2436856170 |
| GSE37065 | Up | 0.2393783319 |
| GSE28863_A1 | Down | -0.0203860934 |
| GSE28863_A2 | Up | 0.0862901515 |
| GSE28863_A3 | Up | 0.0956564758 |
| GSE28863_A4 | Down | -0.0009900394 |
| GSE48662 | Up | 0.0390029701 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Arcitumomab | DB00113 | BTD00107 | BIOD00107 |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23552604 | The CEACAM1 tumor suppressor is an ATM and p53-regulated gene required for the induction of cellular senescence by DNA damage |
| 23552604 | CEACAM1 is an immunoglobulin superfamily member whose expression is frequently lost in human tumors and exhibits tumor-suppressor features in several experimental systems, including Ceacam1 knockout mice |
| 23552604 | There is currently little understanding of the pathways and mechanisms by which CEACAM1 exerts its tumor-suppressor function |
| 23552604 | Here we report that CEACAM1 is strongly upregulated during the cellular response to DNA double-strand breaks (DSBs) starting from the lowest doses of DSB inducers used, and that upregulation is mediated by the ataxia telangiectasia mutated (ATM)/p53 pathway |
| 23552604 | Stable silencing of CEACAM1 showed that CEACAM1 is required for p53-mediated cellular senescence, but not initial cell growth arrest, in response to DNA damage |
| 23552604 | These findings identify CEACAM1 as a key component of the ATM/p53-mediated cellular response to DNA damage, and as a tumor suppressor mediating cellular senescence downstream of p53 |
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