HCSGD entry for SCNN1A

1. General information

Official gene symbolSCNN1A
Entrez ID6337
Gene full namesodium channel, non-voltage-gated 1 alpha subunit
Other gene symbolsBESC2 ENaCa ENaCalpha SCNEA SCNN1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003779Actin bindingIEAmolecular_function
GO:0005272Sodium channel activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005829CytosolIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0006814Sodium ion transportTASbiological_process
GO:0007588ExcretionTASbiological_process
GO:0009897External side of plasma membraneIEAcellular_component
GO:0015280Ligand-gated sodium channel activityIDA IEAmolecular_function
GO:0016021Integral component of membraneIEAcellular_component
GO:0016324Apical plasma membraneIEAcellular_component
GO:0030864Cortical actin cytoskeletonIEAcellular_component
GO:0034220Ion transmembrane transportTASbiological_process
GO:0034706Sodium channel complexIDA IEAcellular_component
GO:0035725Sodium ion transmembrane transportIDAbiological_process
GO:0050699WW domain bindingIEA IPImolecular_function
GO:0050878Regulation of body fluid levelsIEAbiological_process
GO:0050891Multicellular organismal water homeostasisIDAbiological_process
GO:0050896Response to stimulusIEAbiological_process
GO:0050909Sensory perception of tasteIEAbiological_process
GO:0055078Sodium ion homeostasisIDAbiological_process
GO:0055085Transmembrane transportTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.60503338780.90036074240.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0100105466
GSE13712_SHEARUp0.0627927021
GSE13712_STATICUp0.0859790956
GSE19018Up0.1971505820
GSE19899_A1Down-0.0249604680
GSE19899_A2Up0.1178058634
PubMed_21979375_A1Up0.0694312398
PubMed_21979375_A2Down-0.1493603009
GSE35957Up0.1597520774
GSE36640Up0.0597926031
GSE54402Up0.0050193231
GSE9593Down-0.0625415202
GSE43922Up0.0108497057
GSE24585Up0.0205055725
GSE37065Up0.0656783689
GSE28863_A1Up0.0492774365
GSE28863_A2Down-0.0574941734
GSE28863_A3Up0.2654628901
GSE28863_A4Up0.1159899722
GSE48662Up0.0015773799

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

TriamtereneDB00384 APRD00079
AmilorideDB00594 APRD00790 | EXPT00514

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.