HCSGD entry for SCN10A

1. General information

Official gene symbolSCN10A
Entrez ID6336
Gene full namesodium channel, voltage-gated, type X, alpha subunit
Other gene symbolsNav1.8 PN3 SNS hPN3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001518Voltage-gated sodium channel complexIDAcellular_component
GO:0002027Regulation of heart rateIMPbiological_process
GO:0005248Voltage-gated sodium channel activityIDAmolecular_function
GO:0006814Sodium ion transportTASbiological_process
GO:0007600Sensory perceptionTASbiological_process
GO:0034765Regulation of ion transmembrane transportIDAbiological_process
GO:0035725Sodium ion transmembrane transportIDAbiological_process
GO:0044299C-fiberIEAcellular_component
GO:0055117Regulation of cardiac muscle contractionIMPbiological_process
GO:0060371Regulation of atrial cardiac muscle cell membrane depolarizationIMPbiological_process
GO:0086067AV node cell to bundle of His cell communicationIMPbiological_process
GO:0086069Bundle of His cell to Purkinje myocyte communicationIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.67837937010.78304243380.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2139485182
GSE13712_SHEARDown-0.0553155308
GSE13712_STATICDown-0.0376082140
GSE19018Up0.1357321406
GSE19899_A1Up0.1025294471
GSE19899_A2Up0.3163727591
PubMed_21979375_A1Down-0.1131172036
PubMed_21979375_A2Up0.1542049380
GSE35957Up0.2406546657
GSE36640Down-0.0054255797
GSE54402Down-0.0101608287
GSE9593Up0.0170202010
GSE43922Up0.0146087008
GSE24585Up0.0968762935
GSE37065Down-0.1098936747
GSE28863_A1Down-0.0282922328
GSE28863_A2Up0.0659538415
GSE28863_A3Up0.0748907175
GSE28863_A4Down-0.0055998291
GSE48662Up0.0477121230

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

LidocaineDB00281 APRD00479 | DB05291
RopivacaineDB00296 APRD00492
BupivacaineDB00297 APRD00247
HexylcaineDB00473 APRD01014
ProparacaineDB00807 APRD00522
MepivacaineDB00961 APRD01094
LevobupivacaineDB01002 APRD00110
BenzocaineDB01086 APRD00539
ChloroprocaineDB01161 APRD00404
LacosamideDB06218 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.