HCSGD entry for SCN9A
1. General information
| Official gene symbol | SCN9A |
|---|---|
| Entrez ID | 6335 |
| Gene full name | sodium channel, voltage-gated, type IX, alpha subunit |
| Other gene symbols | ETHA FEB3B GEFSP7 NE-NA NENA Nav1.7 PN1 SFNP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001518 | Voltage-gated sodium channel complex | IEA | cellular_component |
| GO:0005216 | Ion channel activity | IEA | molecular_function |
| GO:0005248 | Voltage-gated sodium channel activity | IEA | molecular_function |
| GO:0006814 | Sodium ion transport | TAS | biological_process |
| GO:0006954 | Inflammatory response | IEA | biological_process |
| GO:0009636 | Response to toxic substance | IEA | biological_process |
| GO:0009791 | Post-embryonic development | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0019228 | Neuronal action potential | IEA | biological_process |
| GO:0031402 | Sodium ion binding | IEA | molecular_function |
| GO:0034220 | Ion transmembrane transport | TAS | biological_process |
| GO:0035725 | Sodium ion transmembrane transport | TAS | biological_process |
| GO:0048266 | Behavioral response to pain | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4439215645 | 0.0003892595 | 0.9999902473 | 0.0365917857 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.2926153753 |
| GSE13712_SHEAR | Down | -0.8833762578 |
| GSE13712_STATIC | Down | -0.2044514684 |
| GSE19018 | Up | 0.8405702847 |
| GSE19899_A1 | Down | -0.9085086717 |
| GSE19899_A2 | Down | -2.7066874720 |
| PubMed_21979375_A1 | Down | -4.1978852840 |
| PubMed_21979375_A2 | Down | -4.0471893350 |
| GSE35957 | Up | 0.3510030389 |
| GSE36640 | Up | 1.1878870754 |
| GSE54402 | Down | -2.9897744956 |
| GSE9593 | Up | 0.5779919323 |
| GSE43922 | Down | -1.7071468899 |
| GSE24585 | Up | 0.3273587477 |
| GSE37065 | Down | -0.3191682162 |
| GSE28863_A1 | Down | -0.3532582409 |
| GSE28863_A2 | Up | 0.2567121349 |
| GSE28863_A3 | Down | -0.6458231861 |
| GSE28863_A4 | Down | -0.1179254956 |
| GSE48662 | Up | 0.1981276468 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Ranolazine | DB00243 | APRD01300 |
| Lidocaine | DB00281 | APRD00479 | DB05291 |
| Zonisamide | DB00909 | APRD00004 |
| Rufinamide | DB06201 | - |
| Lacosamide | DB06218 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018700 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
