HCSGD entry for SCN8A

1. General information

Official gene symbolSCN8A
Entrez ID6334
Gene full namesodium channel, voltage gated, type VIII, alpha subunit
Other gene symbolsCERIII CIAT EIEE13 MED NaCh6 Nav1.6 PN4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001518Voltage-gated sodium channel complexIC IEAcellular_component
GO:0005216Ion channel activityIEAmolecular_function
GO:0005248Voltage-gated sodium channel activityIDA IEA NASmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0006814Sodium ion transportNASbiological_process
GO:0007399Nervous system developmentTASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0007422Peripheral nervous system developmentISSbiological_process
GO:0007517Muscle organ developmentIEAbiological_process
GO:0007605Sensory perception of soundIEAbiological_process
GO:0007628Adult walking behaviorIEAbiological_process
GO:0009636Response to toxic substanceIEAbiological_process
GO:0016021Integral component of membraneIEA TAScellular_component
GO:0016023Cytoplasmic membrane-bounded vesicleIEAcellular_component
GO:0030018Z discISScellular_component
GO:0030425DendriteIEAcellular_component
GO:0033268Node of RanvierISScellular_component
GO:0034220Ion transmembrane transportIDA NASbiological_process
GO:0035725Sodium ion transmembrane transportIDA NASbiological_process
GO:0042552MyelinationISSbiological_process
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043194Axon initial segmentISScellular_component
GO:0050905Neuromuscular processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.10008946090.83410374610.65993354211.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0688673673
GSE13712_SHEARUp0.4118702938
GSE13712_STATICUp0.1751397969
GSE19018Down-0.0247548006
GSE19899_A1Up0.0682233981
GSE19899_A2Up0.2293157038
PubMed_21979375_A1Down-0.9593954682
PubMed_21979375_A2Up0.1967086164
GSE35957Up0.0178883895
GSE36640Up0.5520227160
GSE54402Up0.1677579586
GSE9593Up0.1903262509
GSE43922Down-0.1801686069
GSE24585Up0.1882436670
GSE37065Down-0.1748660105
GSE28863_A1Up0.2208675061
GSE28863_A2Up0.1684255345
GSE28863_A3Down-0.2983850787
GSE28863_A4Up0.4333403505
GSE48662Up0.3963799332

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

TetrodotoxinDB05232 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.