HCSGD entry for SCN4B

1. General information

Official gene symbolSCN4B
Entrez ID6330
Gene full namesodium channel, voltage-gated, type IV, beta subunit
Other gene symbolsLQT10 Navbeta4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001518Voltage-gated sodium channel complexIDAcellular_component
GO:0005248Voltage-gated sodium channel activityIDAmolecular_function
GO:0006814Sodium ion transportIDAbiological_process
GO:0010765Positive regulation of sodium ion transportIDAbiological_process
GO:0014704Intercalated discISScellular_component
GO:0017080Sodium channel regulator activityIDAmolecular_function
GO:0035725Sodium ion transmembrane transportIDAbiological_process
GO:0044325Ion channel bindingIPImolecular_function
GO:0060048Cardiac muscle contractionIMPbiological_process
GO:0060307Regulation of ventricular cardiac muscle cell membrane repolarizationIMPbiological_process
GO:0086002Cardiac muscle cell action potential involved in contractionIMPbiological_process
GO:0086006Voltage-gated sodium channel activity involved in cardiac muscle cell action potentialIMPmolecular_function
GO:0086012Membrane depolarization during cardiac muscle cell action potentialIMPbiological_process
GO:0086067AV node cell to bundle of His cell communicationIMPbiological_process
GO:0086091Regulation of heart rate by cardiac conductionIMPbiological_process
GO:2000649Regulation of sodium ion transmembrane transporter activityIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.13856640710.52124022260.74882369721.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1454441427
GSE13712_SHEARDown-0.3302209098
GSE13712_STATICDown-0.0999194118
GSE19018Down-0.1142991665
GSE19899_A1Down-0.2679855028
GSE19899_A2Up0.3584784694
PubMed_21979375_A1Up0.2682348433
PubMed_21979375_A2Up0.5627139879
GSE35957Up0.0921230426
GSE36640Up1.4473649515
GSE54402Down-1.6558782688
GSE9593Up0.2439282508
GSE43922Up0.0935849924
GSE24585Up0.1106388798
GSE37065Down-0.0235108574
GSE28863_A1Down-0.1562090742
GSE28863_A2Down-0.1133071005
GSE28863_A3Up0.4002227886
GSE28863_A4Up0.3074747879
GSE48662Down-0.0095760206

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

ZonisamideDB00909 APRD00004

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-122-5pMIMAT0000421MIRT023310MicroarrayFunctional MTI (Weak)17612493
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.