HCSGD entry for BGLAP

1. General information

Official gene symbolBGLAP
Entrez ID632
Gene full namebone gamma-carboxyglutamate (gla) protein
Other gene symbolsBGP OC OCN
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001501Skeletal system developmentTASbiological_process
GO:0001649Osteoblast differentiationIEPbiological_process
GO:0002076Osteoblast developmentIEAbiological_process
GO:0005198Structural molecule activityNASmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005576Extracellular regionNAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0005791Rough endoplasmic reticulumIEAcellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0007155Cell adhesionNASbiological_process
GO:0007569Cell agingIEAbiological_process
GO:0008147Structural constituent of boneNASmolecular_function
GO:0009612Response to mechanical stimulusIEAbiological_process
GO:0009629Response to gravityIEAbiological_process
GO:0010043Response to zinc ionIEAbiological_process
GO:0014823Response to activityIEAbiological_process
GO:0030282Bone mineralizationNASbiological_process
GO:0030425DendriteIEAcellular_component
GO:0030500Regulation of bone mineralizationIEAbiological_process
GO:0031988Membrane-bounded vesicleIEAcellular_component
GO:0032571Response to vitamin KIEAbiological_process
GO:0033280Response to vitamin DIEPbiological_process
GO:0033574Response to testosteroneIEAbiological_process
GO:0033594Response to hydroxyisoflavoneIEAbiological_process
GO:0042476OdontogenesisNASbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0043204PerikaryonIEAcellular_component
GO:0043627Response to estrogenIEAbiological_process
GO:0045124Regulation of bone resorptionNASbiological_process
GO:0045471Response to ethanolIEAbiological_process
GO:0045670Regulation of osteoclast differentiationNASbiological_process
GO:0046848Hydroxyapatite bindingNASmolecular_function
GO:0051384Response to glucocorticoidIEAbiological_process
GO:0060348Bone developmentIEAbiological_process
GO:0071305Cellular response to vitamin DIEAbiological_process
GO:0071363Cellular response to growth factor stimulusIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01483471750.99947506930.30339129761.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954--
GSE13712_SHEAR--
GSE13712_STATIC--
GSE19018--
GSE19899_A1--
GSE19899_A2--
PubMed_21979375_A1--
PubMed_21979375_A2--
GSE35957--
GSE36640--
GSE54402--
GSE9593--
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.3773985591

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

MenadioneDB00170 NUTR00062
Gamma-Carboxy-Glutamic AcidDB03847 EXPT00902
Gallium nitrateDB05260 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-135b-5pMIMAT0000758MIRT003596qRT-PCRNon-Functional MTI (Weak)19795981
hsa-miR-146a-5pMIMAT0000449MIRT021227qRT-PCRFunctional MTI (Weak)20110513
hsa-miR-192-5pMIMAT0000222MIRT026111MicroarrayFunctional MTI (Weak)19074876
hsa-miR-26b-5pMIMAT0000083MIRT028806MicroarrayFunctional MTI (Weak)19088304
hsa-let-7b-5pMIMAT0000063MIRT032219ProteomicsFunctional MTI (Weak)18668040
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 11 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26170859The expression of alkaline phosphatase (ALP) and osteocalcin (OCN) mRNA was up-regulated at 0
25922305Based on the production of ECM proteins, such as fibronectin, integrin beta1, and collagen type I; alkaline phosphatase (ALP) activity; and the expression of osteogenic genes, such as ALP, Runt-related transcription factor 2, and osteocalcin, cell sheets formed by PDLSCs derived from older donors demonstrated a less potent osteogenic capacity compared to those formed by PDLSCs from younger donors
22067611Also examined were the expression of genes involved in proliferation and mineralization such as human alkaline phosphatase (ALP), beta-actin, collagen 1 (col-1), core binding factor (cbfa-1), dentin matrix protein (DMP-1), dentin sialophosphoprotein (DSPP), GAPDH, hTERT, osteocalcin (OCN), osteopontin (OPN) as well as oncoproteins involved in senescence (p16, p21 and p53) using RT-PCR
21627568However, matrix mineralization and expression of alkaline phosphatase (Alpl) and osteocalcin (Bglap) mRNA after osteogenic induction increased with TDSC passaging
21600109The gene expressions of alkaline phosphatase (ALP), collagen types I (COL I) and osteocalcin (OC) were examined
21324896In addition, a time-dependent reduction in alkaline phosphatase (ALP) activity and osteocalcin mRNA expression was observed in p85alpha(-/-) MSCs compared with WT MSCs, suggesting impaired osteoblast differentiation due to p85alpha deficiency in MSCs
17352650Ex vivo expansion of BMSSCs correlates to an increase in osteogenic lineage associated markers such as alkaline phosphatase, bone sialoprotein, and osteocalcin that are regulated by the master regulatory transcription factor, Cbfa1 (Runx2)
16893911The impaired osteoblast differentiation in Nf1+/- MSPC is consistent with the reduced expression of osteoblast markers at the mRNA level, including osteocalcin and osteonectin
16630306Cell morphology and proliferation were analyzed, and expression of cell-specific gene transcripts and proteins (including collagen types I and III, alkaline phosphatase, bone sialoprotein, osteocalcin, and dentin sialophosphoprotein and dentin matrix protein I) was detected by RT-PCR and immunohistochemistry
11037877METHODS: We examined age-related changes in cellular activity (alkaline phosphatase activity, osteocalcin and C-terminal type I procollagen secretion, and cAMP response to parathyroid hormone), replicative capacity, and senescent cell expression in osteoblasts from periarticular bone samples obtained from 15 patients with RA and 15 age-matched patients with osteoarthritis (OA)
10855706Impairment of osteocalcin production in senescent periodontal ligament fibroblasts
10855706Osteocalcin production of senescent periodontal ligament fibroblasts (PDLF) with the expression of senescence-associated beta-galactosidase (SA-beta-Gal) was investigated on clones from 50-80 years old donors (n=20) with teeth extracted due to periodontitis and dental caries, and from 15-19 year old donors (n=20) with normal teeth extracted for orthodontic reasons
10855706This suggests that the production potential of osteocalcin is impaired in PDLF with aging in culture
10855706Further, the reactive intensity with anti-osteocalcin of PDLF in passage 2 deprived of serum for 48 h was 6% of that of cells cultured with serum and the reaction increased after serum stimulation, suggesting that the osteocalcin production in PDLF in early passage is implicated in mitogenic stimulation
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