HCSGD entry for SC5D
1. General information
| Official gene symbol | SC5D |
|---|---|
| Entrez ID | 6309 |
| Gene full name | sterol-C5-desaturase |
| Other gene symbols | ERG3 S5DES SC5DL |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000248 | C-5 sterol desaturase activity | IEA | molecular_function |
| GO:0005506 | Iron ion binding | IEA | molecular_function |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006629 | Lipid metabolic process | TAS | biological_process |
| GO:0006633 | Fatty acid biosynthetic process | IEA | biological_process |
| GO:0006695 | Cholesterol biosynthetic process | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016491 | Oxidoreductase activity | IEA | molecular_function |
| GO:0033490 | Cholesterol biosynthetic process via lathosterol | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0050046 | Lathosterol oxidase activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0563265719 | 0.4030656738 | 0.5156624131 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3897148341 |
| GSE13712_SHEAR | Down | -0.0107516700 |
| GSE13712_STATIC | Down | -0.1534263069 |
| GSE19018 | Down | -0.4339483861 |
| GSE19899_A1 | Up | 0.5179607846 |
| GSE19899_A2 | Up | 0.1182270477 |
| PubMed_21979375_A1 | Down | -1.5350781380 |
| PubMed_21979375_A2 | Up | 0.3648339906 |
| GSE35957 | Up | 0.3484477485 |
| GSE36640 | Up | 1.8181484854 |
| GSE54402 | Down | -0.9782413319 |
| GSE9593 | Up | 0.5659440170 |
| GSE43922 | Up | 0.1307115919 |
| GSE24585 | Up | 0.0440479108 |
| GSE37065 | Up | 0.3072960033 |
| GSE28863_A1 | Down | -0.0794776289 |
| GSE28863_A2 | Up | 0.3537673692 |
| GSE28863_A3 | Down | -0.4942235081 |
| GSE28863_A4 | Up | 0.0944630661 |
| GSE48662 | Up | 0.0618158013 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018994 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT023105 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038773 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052122 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
