HCSGD entry for SAT1

1. General information

Official gene symbolSAT1
Entrez ID6303
Gene full namespermidine/spermine N1-acetyltransferase 1
Other gene symbolsDC21 KFSD KFSDX SAT SSAT SSAT-1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001525AngiogenesisIEPbiological_process
GO:0004145Diamine N-acetyltransferase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005622IntracellularIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006595Polyamine metabolic processTASbiological_process
GO:0006596Polyamine biosynthetic processTASbiological_process
GO:0008080N-acetyltransferase activityIEAmolecular_function
GO:0009447Putrescine catabolic processIEAbiological_process
GO:0019809Spermidine bindingIEAmolecular_function
GO:0032918Spermidine acetylationIEAbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042127Regulation of cell proliferationIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00002127960.99897920670.01490638301.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.5316078002
GSE13712_SHEARUp0.7901889962
GSE13712_STATICUp0.6633586841
GSE19018Down-0.0404152381
GSE19899_A1Up3.6503260947
GSE19899_A2Up2.6687395361
PubMed_21979375_A1Up2.5474719761
PubMed_21979375_A2Up2.6744475585
GSE35957Up0.4200930796
GSE36640Up1.9512209732
GSE54402Up0.8516348309
GSE9593Up0.0950124164
GSE43922Up2.1616422932
GSE24585Up0.6745137263
GSE37065Up0.7063455517
GSE28863_A1Up0.3545357138
GSE28863_A2Up0.1801163537
GSE28863_A3Up0.8052919409
GSE28863_A4Up0.1250718889
GSE48662Up0.0106470652

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL86940CHEMBL42868P21673
CHEMBL33387CHEMBL42868P21673
CHEMBL315330CHEMBL42868P21673
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  • Drugs

Name

Drug

Accession number

N-ethyl-N-[3-(propylamino)propyl]propane-1,3-diamineDB04633 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT019180MicroarrayFunctional MTI (Weak)18185580
hsa-miR-107MIMAT0000104MIRT026968MicroarrayNon-Functional MTI (Weak)20489155
hsa-miR-744-5pMIMAT0004945MIRT037497CLASHFunctional MTI (Weak)23622248
hsa-miR-455-3pMIMAT0004784MIRT037883CLASHFunctional MTI (Weak)23622248
hsa-miR-652-3pMIMAT0003322MIRT039551CLASHFunctional MTI (Weak)23622248
hsa-miR-100-5pMIMAT0000098MIRT048548CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

17627613It was found that five genes encoding ESE-3, inhibin betaA, RGS5, SSAT and DIO2 were up-regulated in senescent cells induced by RasV12, H(2)O(2) and telomere shortening, but not in quiescent or actively growing cells, suggesting that these genes serve as molecular markers for various types of cellular senescence
17627613In contrast, RGS5, SSAT and the constitutive active form of the inhibin betaA receptor gene did not induce such senescence phenotypes when ectopically expressed
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