HCSGD entry for S100A11
1. General information
| Official gene symbol | S100A11 |
|---|---|
| Entrez ID | 6282 |
| Gene full name | S100 calcium binding protein A11 |
| Other gene symbols | MLN70 S100C |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001726 | Ruffle | IDA | cellular_component |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA TAS | cellular_component |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0008156 | Negative regulation of DNA replication | TAS | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | TAS | biological_process |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0044548 | S100 protein binding | IPI | molecular_function |
| GO:0048306 | Calcium-dependent protein binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0576128187 | 0.7489885187 | 0.5208685293 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2792941554 |
| GSE13712_SHEAR | Up | 0.2411877891 |
| GSE13712_STATIC | Up | 0.1661073991 |
| GSE19018 | Up | 0.7439880661 |
| GSE19899_A1 | Up | 0.2861191570 |
| GSE19899_A2 | Up | 0.6897441208 |
| PubMed_21979375_A1 | Up | 1.2806371516 |
| PubMed_21979375_A2 | Up | 0.3243782448 |
| GSE35957 | Down | -0.1025776676 |
| GSE36640 | Up | 0.2547147273 |
| GSE54402 | Up | 0.1840004464 |
| GSE9593 | Up | 0.2779055995 |
| GSE43922 | Up | 0.0709616228 |
| GSE24585 | Down | -0.6809674062 |
| GSE37065 | Down | -0.0464454765 |
| GSE28863_A1 | Down | -0.2581685568 |
| GSE28863_A2 | Down | -0.0960186018 |
| GSE28863_A3 | Down | -0.1107987772 |
| GSE28863_A4 | Down | -0.1360966039 |
| GSE48662 | Down | -0.2008977597 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Phosphonothreonine | DB02482 | EXPT03092 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020889 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1 | MIMAT0000416 | MIRT023889 | Proteomics | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 11602207 | Up-regulation of S100C in normal human fibroblasts in the process of aging in vitro |
| 11602207 | We previously demonstrated that S100C could move to and accumulate in the nuclei of normal human fibroblasts but not in the nuclei of immortalized and neoplastic cells |
| 11602207 | In the present study, we investigated whether S100C was associated with cellular senescence in vitro |
| 11602207 | We found that S100C expression increased in normal human fibroblasts in the process of aging in culture and was accompanied by accumulation of its protein in the nuclei of senescent fibroblasts |
| 11602207 | In addition, the nuclear accumulation of S100C increased expression of a cyclin-dependent kinase inhibitor p21(Sdi1), a strong inhibitor of cell growth |
| 11602207 | These findings suggest that an increase in the cells having nuclear accumulation of S100C is closely related to the process of cellular senescence of normal human fibroblasts |
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