HCSGD entry for S100A9

1. General information

Official gene symbolS100A9
Entrez ID6280
Gene full nameS100 calcium binding protein A9
Other gene symbols60B8AG CAGB CFAG CGLB L1AG LIAG MAC387 MIF MRP14 NIF P14
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001816Cytokine productionTASbiological_process
GO:0002523Leukocyte migration involved in inflammatory responseIDAbiological_process
GO:0002544Chronic inflammatory responseIEAbiological_process
GO:0004871Signal transducer activityTASmolecular_function
GO:0005509Calcium ion bindingTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005856CytoskeletonTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006914AutophagyIDAbiological_process
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processIDAbiological_process
GO:0006954Inflammatory responseTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0008017Microtubule bindingTASmolecular_function
GO:0008270Zinc ion bindingTASmolecular_function
GO:0010043Response to zinc ionIEAbiological_process
GO:0016209Antioxidant activityIEAmolecular_function
GO:0030307Positive regulation of cell growthTASbiological_process
GO:0030593Neutrophil chemotaxisIDAbiological_process
GO:0032119Sequestering of zinc ionTASbiological_process
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0032602Chemokine productionTASbiological_process
GO:0035662Toll-like receptor 4 bindingTASmolecular_function
GO:0042742Defense response to bacteriumTASbiological_process
GO:0045087Innate immune responseIEAbiological_process
GO:0045471Response to ethanolIEAbiological_process
GO:0050544Arachidonic acid bindingTASmolecular_function
GO:0050729Positive regulation of inflammatory responseIDAbiological_process
GO:0050786RAGE receptor bindingTASmolecular_function
GO:0050832Defense response to fungusTASbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityTASbiological_process
GO:0051493Regulation of cytoskeleton organizationTASbiological_process
GO:0070488Neutrophil aggregationIDAbiological_process
GO:2001244Positive regulation of intrinsic apoptotic signaling pathwayIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.50471024660.70108519050.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0404775976
GSE13712_SHEARUp0.2450244713
GSE13712_STATICUp0.3025775819
GSE19018Down-0.1983740669
GSE19899_A1Down-0.0514830829
GSE19899_A2Up0.0442219775
PubMed_21979375_A1Up0.0817246621
PubMed_21979375_A2Up0.2118230412
GSE35957Down-0.1167158361
GSE36640Up0.0533411096
GSE54402Up0.0536763992
GSE9593Down-0.3941326931
GSE43922Up0.0443062181
GSE24585Up0.0524501891
GSE37065Down-0.1291507262
GSE28863_A1Up0.1935982624
GSE28863_A2Down-0.0768496540
GSE28863_A3Up0.0217704470
GSE28863_A4Up0.2915988495
GSE48662Down-0.0402831386

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-196a-5pMIMAT0000226MIRT000220Luciferase reporter assay//qRT-PCRFunctional MTI19342367
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-196a-5pMIMAT00002261hsa-miR-196a19342367
hsa-miR-451aMIMAT00016311hsa-miR-451{Western blot}{overexpression by miRNA precursor transfection}19318487
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.