HCSGD entry for S100A8

1. General information

Official gene symbolS100A8
Entrez ID6279
Gene full nameS100 calcium binding protein A8
Other gene symbols60B8AG CAGA CFAG CGLA CP-10 L1Ag MA387 MIF MRP8 NIF P8
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001816Cytokine productionTASbiological_process
GO:0002523Leukocyte migration involved in inflammatory responseIDAbiological_process
GO:0002526Acute inflammatory responseIEAbiological_process
GO:0002544Chronic inflammatory responseIEAbiological_process
GO:0005509Calcium ion bindingTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005856CytoskeletonTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006914AutophagyIDAbiological_process
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processIDAbiological_process
GO:0006954Inflammatory responseTASbiological_process
GO:0008017Microtubule bindingTASmolecular_function
GO:0008270Zinc ion bindingTASmolecular_function
GO:0010043Response to zinc ionIEAbiological_process
GO:0030307Positive regulation of cell growthTASbiological_process
GO:0030593Neutrophil chemotaxisIDAbiological_process
GO:0032119Sequestering of zinc ionTASbiological_process
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0032602Chemokine productionTASbiological_process
GO:0035662Toll-like receptor 4 bindingTASmolecular_function
GO:0042060Wound healingIEAbiological_process
GO:0042742Defense response to bacteriumTASbiological_process
GO:0045087Innate immune responseIEAbiological_process
GO:0045471Response to ethanolIEAbiological_process
GO:0050544Arachidonic acid bindingTASmolecular_function
GO:0050729Positive regulation of inflammatory responseIDAbiological_process
GO:0050786RAGE receptor bindingTASmolecular_function
GO:0050832Defense response to fungusTASbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityTASbiological_process
GO:0051493Regulation of cytoskeleton organizationTASbiological_process
GO:0070488Neutrophil aggregationIDAbiological_process
GO:2001244Positive regulation of intrinsic apoptotic signaling pathwayIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.59938707500.71259042210.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0577059165
GSE13712_SHEARDown-0.1678143847
GSE13712_STATICDown-0.0780590339
GSE19018Up0.1631369251
GSE19899_A1Up0.1131836780
GSE19899_A2Up0.1265322096
PubMed_21979375_A1Up0.0955668770
PubMed_21979375_A2Up0.1570019746
GSE35957Down-0.1304765940
GSE36640Down-0.1302378022
GSE54402Up0.1818656739
GSE9593Down-0.9383694250
GSE43922Up0.0190010831
GSE24585Up0.2586128169
GSE37065Down-0.0373852311
GSE28863_A1Up0.0392333133
GSE28863_A2Down-0.1413241530
GSE28863_A3Up0.1508470098
GSE28863_A4Down-0.0014736265
GSE48662Down-0.0518895463

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-98-5pMIMAT0000096MIRT027768MicroarrayFunctional MTI (Weak)19088304
hsa-miR-125b-5pMIMAT0000423MIRT045918CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

1996991The Cystic Fibrosis antigen (CFA) is a 14 kDa
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