HCSGD entry for S100A1
1. General information
| Official gene symbol | S100A1 |
|---|---|
| Entrez ID | 6271 |
| Gene full name | S100 calcium binding protein A1 |
| Other gene symbols | S100 S100-alpha S100A |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0008016 | Regulation of heart contraction | IEA NAS | biological_process |
| GO:0016529 | Sarcoplasmic reticulum | IDA IEA | cellular_component |
| GO:0030018 | Z disc | IEA | cellular_component |
| GO:0031430 | M band | IEA | cellular_component |
| GO:0035556 | Intracellular signal transduction | NAS | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0042803 | Protein homodimerization activity | IDA IEA | molecular_function |
| GO:0043005 | Neuron projection | IEA | cellular_component |
| GO:0043234 | Protein complex | NAS | cellular_component |
| GO:0044548 | S100 protein binding | IPI | molecular_function |
| GO:0048306 | Calcium-dependent protein binding | IEA | molecular_function |
| GO:0051117 | ATPase binding | IPI | molecular_function |
| GO:1901387 | Positive regulation of voltage-gated calcium channel activity | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1680324456 | 0.7029187759 | 0.8088764717 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0659331954 |
| GSE13712_SHEAR | Down | -0.2880453053 |
| GSE13712_STATIC | Down | -0.1254558816 |
| GSE19018 | Up | 0.0633119903 |
| GSE19899_A1 | Up | 0.2014113782 |
| GSE19899_A2 | Down | -0.0894096217 |
| PubMed_21979375_A1 | Down | -0.0831898338 |
| PubMed_21979375_A2 | Down | -0.1414037297 |
| GSE35957 | Up | 0.2917240979 |
| GSE36640 | Up | 0.1718578246 |
| GSE54402 | Down | -0.0141329095 |
| GSE9593 | Up | 0.1305267107 |
| GSE43922 | Up | 0.2993383719 |
| GSE24585 | Up | 0.2539078746 |
| GSE37065 | Up | 0.0642287573 |
| GSE28863_A1 | Down | -0.3593020771 |
| GSE28863_A2 | Down | -0.1564759723 |
| GSE28863_A3 | Up | 0.2495152838 |
| GSE28863_A4 | Up | 0.6019844320 |
| GSE48662 | Up | 0.0287221303 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Olopatadine | DB00768 | APRD00310 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-132-3p | MIMAT0000426 | MIRT021738 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT025080 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028823 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 19526322 | The mRNA levels of CCAAT/enhancer-binding protein (C/EBP)alpha, peroxisome proliferator-activated receptor (PPAR)gamma and S100A1 were maximal during adipocyte differentiation and then significantly decreased |
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