HCSGD entry for BDNF

1. General information

Official gene symbolBDNF
Entrez ID627
Gene full namebrain-derived neurotrophic factor
Other gene symbolsANON2 BULN2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001657Ureteric bud developmentIEAbiological_process
GO:0001662Behavioral fear responseIEAbiological_process
GO:0001666Response to hypoxiaIEAbiological_process
GO:0002544Chronic inflammatory responseIEAbiological_process
GO:0005169Neurotrophin TRKB receptor bindingIEAmolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0005737CytoplasmISScellular_component
GO:0006120Mitochondrial electron transport, NADH to ubiquinoneIEAbiological_process
GO:0007399Nervous system developmentTASbiological_process
GO:0007406Negative regulation of neuroblast proliferationIEAbiological_process
GO:0007411Axon guidanceIEAbiological_process
GO:0007412Axon target recognitionIEAbiological_process
GO:0007611Learning or memoryIEAbiological_process
GO:0007631Feeding behaviorIEAbiological_process
GO:0008021Synaptic vesicleIEAcellular_component
GO:0008038Neuron recognitionIEAbiological_process
GO:0008083Growth factor activityIEAmolecular_function
GO:0009725Response to hormoneIEAbiological_process
GO:0014047Glutamate secretionIEAbiological_process
GO:0014076Response to fluoxetineIEAbiological_process
GO:0016358Dendrite developmentIEAbiological_process
GO:0019222Regulation of metabolic processIEAbiological_process
GO:0021675Nerve developmentIEAbiological_process
GO:0033189Response to vitamin AIEAbiological_process
GO:0042490Mechanoreceptor differentiationIEAbiological_process
GO:0043524Negative regulation of neuron apoptotic processIEAbiological_process
GO:0045666Positive regulation of neuron differentiationIEAbiological_process
GO:0045843Negative regulation of striated muscle tissue developmentIEAbiological_process
GO:0046668Regulation of retinal cell programmed cell deathIEAbiological_process
GO:0048170Positive regulation of long-term neuronal synaptic plasticityIEAbiological_process
GO:0048172Regulation of short-term neuronal synaptic plasticityIEAbiological_process
GO:0048471Perinuclear region of cytoplasmISScellular_component
GO:0048839Inner ear developmentIEAbiological_process
GO:0051965Positive regulation of synapse assemblyIDAbiological_process
GO:0055093Response to hyperoxiaIEAbiological_process
GO:0060079Regulation of excitatory postsynaptic membrane potentialIEAbiological_process
GO:0072347Response to anestheticIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.14609704800.00010037230.76632530890.0176126667

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-1.7177062364
GSE13712_SHEARUp1.4399466033
GSE13712_STATICUp2.8630154419
GSE19018Down-0.0082990858
GSE19899_A1Down-2.5423518908
GSE19899_A2Down-1.6823240688
PubMed_21979375_A1Down-2.4741123223
PubMed_21979375_A2Down-3.5949073022
GSE35957Up0.2266074740
GSE36640Up0.8668777091
GSE54402Down-1.8904194531
GSE9593Up0.9413160668
GSE43922Down-1.4940705825
GSE24585Up0.1545156228
GSE37065Up0.3333376468
GSE28863_A1Down-1.1085048133
GSE28863_A2Down-1.4229920812
GSE28863_A3Down-1.1213646298
GSE28863_A4Down-0.1563285504
GSE48662Down-0.2308083683

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

CX717DB05047 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT002955Luciferase reporter assayFunctional MTI14697198
hsa-miR-210-3pMIMAT0000267MIRT0031532DGE//immunoprecipitaion//Luciferase reporter assay//Mass spectrometry//Microarray//qRT-PCR//Western blotFunctional MTI19826008
hsa-miR-22-3pMIMAT0000077MIRT005900Luciferase reporter assay//MicroarrayFunctional MTI21168126
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23600401The behavioural alterations were associated with a decreased number of proliferating cells and lower expression of brain-derived neurotrophic factor (Bdnf) mRNA in the hippocampal dentate gyrus
23600401MeHg exposure also induced long-lasting DNA hypermethylation, increased histone H3-K27 tri-methylation and decreased H3 acetylation at the Bdnf promoter IV, indicating that epigenetic mechanisms play a critical role in mediating the long-lasting effects of perinatal exposure to MeHg
23600401Fluoxetine treatment restored the Bdnf mRNA expression levels, as well as the number of proliferating cells in the granule cell layer of the dentate gyrus, which further supports the hypothesis that links depression to impaired neurogenesis
17635673The neurotrophin receptor tropomyosin-related kinase A (TrkA) and its ligand nerve growth factor (NGF) are expressed in astrocytomas, and an inverse association of TrkA expression with malignancy grade was described
14992815Northern analysis showed greater expression of two aging-associated genes, p21 and brain-derived neurotrophic factor (BDNF) in the aged hippocampus
14992815The age-related differences in p21 and BDNF expression were particularly prominent after TBI
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