HCSGD entry for RYR2

1. General information

Official gene symbolRYR2
Entrez ID6262
Gene full nameryanodine receptor 2 (cardiac)
Other gene symbolsARVC2 ARVD2 RYR-2 RyR VTSIP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001666Response to hypoxiaIEA ISSbiological_process
GO:0002027Regulation of heart rateIMPbiological_process
GO:0003143Embryonic heart tube morphogenesisIEA ISSbiological_process
GO:0003220Left ventricular cardiac muscle tissue morphogenesisIEA ISSbiological_process
GO:0003300Cardiac muscle hypertrophyIEA ISSbiological_process
GO:0005218Intracellular ligand-gated calcium channel activityISSmolecular_function
GO:0005219Ryanodine-sensitive calcium-release channel activityIDA IEAmolecular_function
GO:0005262Calcium channel activityISSmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005513Detection of calcium ionIDAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005516Calmodulin bindingIEA IMP IPI ISSmolecular_function
GO:0005886Plasma membraneISScellular_component
GO:0006816Calcium ion transportIDAbiological_process
GO:0006874Cellular calcium ion homeostasisIEA ISSbiological_process
GO:0010460Positive regulation of heart rateIEA ISSbiological_process
GO:0010881Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionIC IEA ISSbiological_process
GO:0014701Junctional sarcoplasmic reticulum membraneTAScellular_component
GO:0014808Release of sequestered calcium ion into cytosol by sarcoplasmic reticulumIEA IMP ISSbiological_process
GO:0015278Calcium-release channel activityIDAmolecular_function
GO:0016020MembraneIDAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016529Sarcoplasmic reticulumIDAcellular_component
GO:0019722Calcium-mediated signalingISSbiological_process
GO:0019899Enzyme bindingIPImolecular_function
GO:0019901Protein kinase bindingIEAmolecular_function
GO:0030018Z discIEA ISScellular_component
GO:0030509BMP signaling pathwayIEAbiological_process
GO:0031000Response to caffeineIDAbiological_process
GO:0033017Sarcoplasmic reticulum membraneIEA ISS TAScellular_component
GO:0034220Ion transmembrane transportTASbiological_process
GO:0034236Protein kinase A catalytic subunit bindingIDAmolecular_function
GO:0034237Protein kinase A regulatory subunit bindingIDAmolecular_function
GO:0034704Calcium channel complexIDA IEAcellular_component
GO:0035584Calcium-mediated signaling using intracellular calcium sourceIDAbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0043234Protein complexIDAcellular_component
GO:0043621Protein self-associationIEAmolecular_function
GO:0043924Suramin bindingIMPmolecular_function
GO:0044325Ion channel bindingISSmolecular_function
GO:0048763Calcium-induced calcium release activityIDAmolecular_function
GO:0051209Release of sequestered calcium ion into cytosolIDA ISSbiological_process
GO:0051284Positive regulation of sequestering of calcium ionIDAbiological_process
GO:0051480Cytosolic calcium ion homeostasisISSbiological_process
GO:0051775Response to redox stateIDAbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0055117Regulation of cardiac muscle contractionIMPbiological_process
GO:0060048Cardiac muscle contractionIMPbiological_process
GO:0060070Canonical Wnt signaling pathwayIEAbiological_process
GO:0060402Calcium ion transport into cytosolIDAbiological_process
GO:0070296Sarcoplasmic reticulum calcium ion transportTASbiological_process
GO:0071313Cellular response to caffeineIDA IEA ISSbiological_process
GO:0071872Cellular response to epinephrine stimulusTASbiological_process
GO:0072599Establishment of protein localization to endoplasmic reticulumIDAbiological_process
GO:0086005Ventricular cardiac muscle cell action potentialIEA ISSbiological_process
GO:0086029Purkinje myocyte to ventricular cardiac muscle cell signalingIEA ISSbiological_process
GO:0086064Cell communication by electrical coupling involved in cardiac conductionICbiological_process
GO:0086094Positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contractionIEA ISSbiological_process
GO:0097050Type B pancreatic cell apoptotic processIEA IMPbiological_process
GO:1901896Positive regulation of calcium-transporting ATPase activityIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.89548264500.63317739450.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0046572280
GSE13712_SHEARDown-0.1767716957
GSE13712_STATICUp0.0290555228
GSE19018Up0.0730011915
GSE19899_A1Up0.0000114334
GSE19899_A2Down-0.0953910276
PubMed_21979375_A1Up0.1409314445
PubMed_21979375_A2Down-0.0215203034
GSE35957Up0.0978413080
GSE36640Up0.1620667052
GSE54402Up0.0654618044
GSE9593Up0.0884049218
GSE43922Up0.0069805863
GSE24585Down-0.4752397650
GSE37065Down-0.0488834061
GSE28863_A1Down-0.0929434415
GSE28863_A2Up0.1025436277
GSE28863_A3Up0.0995406201
GSE28863_A4Down-0.0186620383
GSE48662Down-0.0274503610

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017941MicroarrayFunctional MTI (Weak)18185580
hsa-miR-25-3pMIMAT0000081MIRT050316CLASHFunctional MTI (Weak)23622248
hsa-miR-17-5pMIMAT0000070MIRT050849CLASHFunctional MTI (Weak)23622248
hsa-let-7c-5pMIMAT0000064MIRT051746CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.