HCSGD entry for RXRA
1. General information
| Official gene symbol | RXRA |
|---|---|
| Entrez ID | 6256 |
| Gene full name | retinoid X receptor, alpha |
| Other gene symbols | NR2B1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IDA IEA | biological_process |
| GO:0000790 | Nuclear chromatin | IDA | cellular_component |
| GO:0001701 | In utero embryonic development | IEA | biological_process |
| GO:0001893 | Maternal placenta development | IEA | biological_process |
| GO:0003677 | DNA binding | IDA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IDA | molecular_function |
| GO:0003707 | Steroid hormone receptor activity | IEA | molecular_function |
| GO:0003708 | Retinoic acid receptor activity | TAS | molecular_function |
| GO:0003713 | Transcription coactivator activity | TAS | molecular_function |
| GO:0004879 | Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity | IDA | molecular_function |
| GO:0004886 | 9-cis retinoic acid receptor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0006766 | Vitamin metabolic process | TAS | biological_process |
| GO:0007566 | Embryo implantation | IEA | biological_process |
| GO:0008134 | Transcription factor binding | IEA | molecular_function |
| GO:0008203 | Cholesterol metabolic process | TAS | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0019048 | Modulation by virus of host morphology or physiology | IDA | biological_process |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0031490 | Chromatin DNA binding | IEA | molecular_function |
| GO:0032526 | Response to retinoic acid | IMP | biological_process |
| GO:0035357 | Peroxisome proliferator activated receptor signaling pathway | IDA | biological_process |
| GO:0042809 | Vitamin D receptor binding | IPI | molecular_function |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0044212 | Transcription regulatory region DNA binding | IDA IEA | molecular_function |
| GO:0044255 | Cellular lipid metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0044323 | Retinoic acid-responsive element binding | IDA | molecular_function |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA IEA | biological_process |
| GO:0046982 | Protein heterodimerization activity | IDA | molecular_function |
| GO:0048384 | Retinoic acid receptor signaling pathway | IMP | biological_process |
| GO:0055010 | Ventricular cardiac muscle tissue morphogenesis | IEA | biological_process |
| GO:0055012 | Ventricular cardiac muscle cell differentiation | IEA | biological_process |
| GO:0060038 | Cardiac muscle cell proliferation | IEA | biological_process |
| GO:0060528 | Secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development | IEA | biological_process |
| GO:0060687 | Regulation of branching involved in prostate gland morphogenesis | IEA | biological_process |
| GO:0070644 | Vitamin D response element binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9416228487 | 0.1662491243 | 0.9999902473 | 0.7890918452 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0962488512 |
| GSE13712_SHEAR | Down | -0.2988895978 |
| GSE13712_STATIC | Down | -0.2343591510 |
| GSE19018 | Up | 0.0159267646 |
| GSE19899_A1 | Down | -0.2572936671 |
| GSE19899_A2 | Down | -0.0805943393 |
| PubMed_21979375_A1 | Down | -0.5298008331 |
| PubMed_21979375_A2 | Down | -0.0352153012 |
| GSE35957 | Down | -0.3992881669 |
| GSE36640 | Up | 0.0531440396 |
| GSE54402 | Down | -0.1568364650 |
| GSE9593 | Down | -0.5929036754 |
| GSE43922 | Up | 0.0498911920 |
| GSE24585 | Down | -0.1215901594 |
| GSE37065 | Down | -0.2192205344 |
| GSE28863_A1 | Up | 0.0825869244 |
| GSE28863_A2 | Up | 0.1187575582 |
| GSE28863_A3 | Up | 0.1467450692 |
| GSE28863_A4 | Up | 0.0869525486 |
| GSE48662 | Up | 0.1413379451 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Adapalene | DB00210 | APRD00780 |
| Etretinate | DB00926 | APRD00966 |
| (5BETA)-PREGNANE-3,20-DIONE | DB07557 | - |
| 2-chloro-5-nitro-N-phenylbenzamide | DB07863 | - |
| 1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE | DB08063 | - |
| 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID | DB08402 | - |
| tributylstannanyl | DB08601 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-423-3p | MIMAT0001340 | MIRT042547 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
