HCSGD entry for RSU1
1. General information
| Official gene symbol | RSU1 |
|---|---|
| Entrez ID | 6251 |
| Gene full name | Ras suppressor protein 1 |
| Other gene symbols | RSP-1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007265 | Ras protein signal transduction | IEA | biological_process |
| GO:0034329 | Cell junction assembly | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7177359979 | 0.4645432164 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1306722661 |
| GSE13712_SHEAR | Down | -0.0559179818 |
| GSE13712_STATIC | Down | -0.0119533311 |
| GSE19018 | Down | -0.0068429367 |
| GSE19899_A1 | Up | 0.0076205430 |
| GSE19899_A2 | Up | 0.4516813555 |
| PubMed_21979375_A1 | Up | 0.3830509887 |
| PubMed_21979375_A2 | Up | 0.1710629313 |
| GSE35957 | Up | 0.0887387389 |
| GSE36640 | Up | 0.3479936483 |
| GSE54402 | Up | 0.0560045605 |
| GSE9593 | Down | -0.0338846770 |
| GSE43922 | Up | 0.0372753470 |
| GSE24585 | Down | -0.3858108775 |
| GSE37065 | Down | -0.1061681984 |
| GSE28863_A1 | Down | -0.0216523616 |
| GSE28863_A2 | Down | -0.1706105957 |
| GSE28863_A3 | Down | -0.2842191802 |
| GSE28863_A4 | Up | 0.1640926657 |
| GSE48662 | Down | -0.5269854754 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025432 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025779 | Microarray | Functional MTI (Weak) | 19073608 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 19925638 | Identified proteins could be classified into several functional categories: (i) cytoskeletal regulators: CapG and cofilin 1; (ii) stress response and signal pathway proteins: TXNDC5 and RSU-1; and (iii) apoptosis proteins: Annexin V |
| 19925638 | We confirmed by Western blot a decrease of RSU-1, CapG and TXNDC5 in PBMCs from old donors |
| 19925638 | RSU-1, which regulates signal transduction of the downstream Ras, showed decreased mRNA and protein levels in PBMCs from old donors and decreased mRNA levels in HDMECs treated with sera from old donors |
| 19925638 | These data indicate that reduced RSU-1 might induce Ras expression, which subsequently could provoke Ras-induced senescence |
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