HCSGD entry for RPS6KA1

1. General information

Official gene symbolRPS6KA1
Entrez ID6195
Gene full nameribosomal protein S6 kinase, 90kDa, polypeptide 1
Other gene symbolsHU-1 MAPKAPK1A RSK RSK1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000287Magnesium ion bindingIEAmolecular_function
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0004672Protein kinase activityIEAmolecular_function
GO:0004674Protein serine/threonine kinase activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005819SpindleIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0007049Cell cycleIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0030307Positive regulation of cell growthTASbiological_process
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0043027Cysteine-type endopeptidase inhibitor activity involved in apoptotic processIDAmolecular_function
GO:0043066Negative regulation of apoptotic processIMPbiological_process
GO:0043154Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processIDAbiological_process
GO:0043555Regulation of translation in response to stressTASbiological_process
GO:0043620Regulation of DNA-templated transcription in response to stressTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045597Positive regulation of cell differentiationTASbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0051403Stress-activated MAPK cascadeTASbiological_process
GO:2000491Positive regulation of hepatic stellate cell activationIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.04032091110.91417704110.45084396771.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1453008933
GSE13712_SHEARUp0.7326529598
GSE13712_STATICUp1.2351660871
GSE19018Up0.3220375762
GSE19899_A1Down-0.0147726054
GSE19899_A2Up1.0774011805
PubMed_21979375_A1Up0.4773747573
PubMed_21979375_A2Up0.3215586819
GSE35957Down-0.2584979599
GSE36640Down-0.3726228408
GSE54402Up0.2676589986
GSE9593Down-0.2819660410
GSE43922Up0.2700371128
GSE24585Up0.3892291280
GSE37065Up0.1013388116
GSE28863_A1Down-0.0718912584
GSE28863_A2Up0.1225246499
GSE28863_A3Up0.1960498143
GSE28863_A4Up0.0277135805
GSE48662Down-0.0616718293

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Purvalanol ADB04751 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-125b-5pMIMAT0000423MIRT006430Luciferase reporter assay//ELISA//GFP reporter assay//Immunoblot//Immunoprecipitaion//qRT-PCR//Western blotFunctional MTI21643012
hsa-miR-193b-3pMIMAT0002819MIRT041478CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25945449RESULTS: Different transcriptional profiles were observed in young, pre-senescent and senescent HDFs, in which cellular aging increased AKT, FOXO3, CDKN1A and RSK1 mRNA expression level, but decreased ELK1, FOS and SIRT1 mRNA expression level
25945449With tocotrienol-rich fraction treatment, gene expression of AKT, FOXO3, ERK and RSK1 mRNA was decreased in senescent cells, but not in young cells
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