HCSGD entry for RPS6

1. General information

Official gene symbolRPS6
Entrez ID6194
Gene full nameribosomal protein S6
Other gene symbolsS6
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000184Nuclear-transcribed mRNA catabolic process, nonsense-mediated decayTASbiological_process
GO:0003735Structural constituent of ribosomeIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005840RibosomeIEAcellular_component
GO:0006364RRNA processingIMPbiological_process
GO:0006412TranslationIC IEA TASbiological_process
GO:0006413Translational initiationTASbiological_process
GO:0006414Translational elongationTASbiological_process
GO:0006415Translational terminationTASbiological_process
GO:0006614SRP-dependent cotranslational protein targeting to membraneTASbiological_process
GO:0008286Insulin receptor signaling pathwayTASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0015935Small ribosomal subunitIDAcellular_component
GO:0016032Viral processTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0019058Viral life cycleTASbiological_process
GO:0019083Viral transcriptionTASbiological_process
GO:0019901Protein kinase bindingIPImolecular_function
GO:0022627Cytosolic small ribosomal subunitIDA NAScellular_component
GO:0030529Ribonucleoprotein complexIDAcellular_component
GO:0031929TOR signalingIDAbiological_process
GO:0042274Ribosomal small subunit biogenesisIMPbiological_process
GO:0042593Glucose homeostasisIEA ISSbiological_process
GO:0043065Positive regulation of apoptotic processIDAbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.96992352490.19385930630.99999024730.8532635011

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0000410160
GSE13712_SHEARDown-0.1159473165
GSE13712_STATICDown-0.1443848785
GSE19018Up0.0066152341
GSE19899_A1Down-0.0980398912
GSE19899_A2Down-0.1422734908
PubMed_21979375_A1Up0.1445393043
PubMed_21979375_A2Down-0.2020085058
GSE35957Down-0.0003050333
GSE36640Down-0.2321859203
GSE54402Up0.0092832805
GSE9593Down-0.0054918259
GSE43922Down-0.1545385216
GSE24585Down-0.0201957793
GSE37065Down-0.1501218473
GSE28863_A1Down-0.0337550386
GSE28863_A2Down-0.2159410068
GSE28863_A3Down-0.0398094402
GSE28863_A4Up0.1572577928
GSE48662Down-0.4164918581

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-16-5pMIMAT0000069MIRT003326ProteomicsFunctional MTI (Weak)18668040
hsa-miR-744-5pMIMAT0004945MIRT037442CLASHFunctional MTI (Weak)23622248
hsa-miR-652-3pMIMAT0003322MIRT039518CLASHFunctional MTI (Weak)23622248
hsa-miR-15b-5pMIMAT0000417MIRT046422CLASHFunctional MTI (Weak)23622248
hsa-miR-182-3pMIMAT0000260MIRT047174CLASHFunctional MTI (Weak)23622248
hsa-miR-99a-5pMIMAT0000097MIRT048636CLASHFunctional MTI (Weak)23622248
hsa-let-7d-5pMIMAT0000065MIRT051718CLASHFunctional MTI (Weak)23622248
hsa-miR-1260bMIMAT0015041MIRT052691CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25484082Using human nonsenescent "young" and replicative senescent endothelial cells as well as Apolipoprotein E-deficient (apoe(-/-)Arg2(+/+)) and Arg2-deficient apoe(-/-) (apoe(-/-)arg2(-/-)) mice fed a high-fat diet for 10 wk as the atherosclerotic animal model, we show here that overexpression of ARG2 in the young cells suppresses endothelial autophagy with concomitant enhanced expression of RICTOR, the essential component of the MTORC2 complex, leading to activation of the AKT-MTORC1-RPS6KB1/S6K1 (ribosomal protein S6 kinase, 70kDa, polypeptide 1) cascade and inhibition of PRKAA/AMPK (protein kinase, AMP-activated, alpha catalytic subunit)
24677687Specifically, effectiveness of these agents to attenuate the level of constitutive mTOR signaling was tested by cytometry and confirmed by Western blotting through measuring phosphorylation of the mTOR-downstream targets including ribosomal protein S6
23832324The activation of p66Shc but not p53 by Arg-II was dependent on extracellular signal-regulated kinases (ERKs) and sequential activation of 40S ribosomal protein S6 kinase 1 (S6K1)-c-Jun N-terminal kinases (JNKs)
23363784They all also decreased the level of intracellular ROS and mitochondrial trans-membrane potential DeltaPsim, the marker of mitochondrial energizing as well as reduced phosphorylation of mTOR, RP-S6 and 4EBP1
16915281Notably, Pml-/- cells and tumours display higher sensitivity both in vitro and in vivo to growth inhibition by rapamycin, and lack of PML inversely correlates with phosphorylation of ribosomal protein S6 and tumour angiogenesis in mouse and human tumours
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