HCSGD entry for RPL11

1. General information

Official gene symbolRPL11
Entrez ID6135
Gene full nameribosomal protein L11
Other gene symbolsDBA7 GIG34 L11
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000184Nuclear-transcribed mRNA catabolic process, nonsense-mediated decayTASbiological_process
GO:0003723RNA bindingTASmolecular_function
GO:0003735Structural constituent of ribosomeIEA NASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005730NucleolusIDA IEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005840RibosomeIEAcellular_component
GO:0006364RRNA processingIMPbiological_process
GO:0006412TranslationIEA NAS TASbiological_process
GO:0006413Translational initiationTASbiological_process
GO:0006414Translational elongationTASbiological_process
GO:0006415Translational terminationTASbiological_process
GO:0006605Protein targetingIMPbiological_process
GO:0006614SRP-dependent cotranslational protein targeting to membraneTASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016032Viral processTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0019058Viral life cycleTASbiological_process
GO:0019083Viral transcriptionTASbiological_process
GO:0019843RRNA bindingIEAmolecular_function
GO:0022625Cytosolic large ribosomal subunitIDAcellular_component
GO:0034504Protein localization to nucleusIEA ISSbiological_process
GO:0042273Ribosomal large subunit biogenesisIMPbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.94326953760.25705450780.99999024730.9719942537

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0055333013
GSE13712_SHEARDown-0.1093738005
GSE13712_STATICDown-0.1524280890
GSE19018Down-0.0052709659
GSE19899_A1Up0.0843590096
GSE19899_A2Down-0.2084181772
PubMed_21979375_A1Up0.4564839366
PubMed_21979375_A2Down-0.2484899025
GSE35957Down-0.2121439223
GSE36640Down-0.3455078345
GSE54402Up0.1995217437
GSE9593Up0.0269461185
GSE43922Down-0.0557119980
GSE24585Up0.0202209937
GSE37065Down-0.4572967211
GSE28863_A1Up0.0378532133
GSE28863_A2Up0.0832270203
GSE28863_A3Down-0.0602404728
GSE28863_A4Up0.0573735843
GSE48662Down-0.3720782872

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Alpha-Hydroxy-Beta-Phenyl-Propionic AcidDB02494 EXPT01733
AnisomycinDB07374 -
PuromycinDB08437 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-505-5pMIMAT0004776MIRT037976CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT048974CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25785348This includes several translation initiation factors (eIF2C2, eIF2B4, eIF3I, eIF3L, eIF4A1) and elongation factors (eEF1G, eEF1A) as well as 40S (RPS4X, RPS7, RPS11 and RPS20) and 60S ribosomal subunits (RPL10, RPL11, RPL18 and RPL35a)
25732822The 5S ribonucleoprotein particle (RNP) complex, consisting of RPL11, RPL5, and 5S rRNA, is implicated in p53 regulation under ribotoxic stress
25732822Oncogenic stress accelerates rRNA transcription and replicative stress delays rRNA processing, resulting in RPL11 and RPL5 accumulation in the ribosome-free fraction, where they bind MDM2
24704832Importantly, silencing of PRAS40 induces upregulation of p53 in a manner dependent on RPL11
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