HCSGD entry for RPL3
1. General information
| Official gene symbol | RPL3 |
|---|---|
| Entrez ID | 6122 |
| Gene full name | ribosomal protein L3 |
| Other gene symbols | ASC-1 L3 TARBP-B |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000184 | Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | TAS | biological_process |
| GO:0003723 | RNA binding | TAS | molecular_function |
| GO:0003735 | Structural constituent of ribosome | IEA NAS | molecular_function |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005840 | Ribosome | IEA | cellular_component |
| GO:0006412 | Translation | IEA NAS TAS | biological_process |
| GO:0006413 | Translational initiation | TAS | biological_process |
| GO:0006414 | Translational elongation | TAS | biological_process |
| GO:0006415 | Translational termination | TAS | biological_process |
| GO:0006614 | SRP-dependent cotranslational protein targeting to membrane | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016032 | Viral process | TAS | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0016071 | MRNA metabolic process | TAS | biological_process |
| GO:0019058 | Viral life cycle | TAS | biological_process |
| GO:0019083 | Viral transcription | TAS | biological_process |
| GO:0022625 | Cytosolic large ribosomal subunit | IDA | cellular_component |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0071353 | Cellular response to interleukin-4 | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9974914061 | 0.0130829984 | 0.9999902473 | 0.2254995422 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0031206244 |
| GSE13712_SHEAR | Down | -0.6407186369 |
| GSE13712_STATIC | Down | -0.4545196308 |
| GSE19018 | Down | -0.0368099870 |
| GSE19899_A1 | Down | -0.2674129082 |
| GSE19899_A2 | Down | -0.2885037384 |
| PubMed_21979375_A1 | Down | -0.5745525214 |
| PubMed_21979375_A2 | Down | -0.7364003933 |
| GSE35957 | Down | -0.2891110442 |
| GSE36640 | Down | -0.4169335614 |
| GSE54402 | Down | -0.1200237023 |
| GSE9593 | Down | -0.0637156932 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Down | -0.4165752712 |
| GSE28863_A2 | Down | -0.1162517266 |
| GSE28863_A3 | Down | -0.1874464193 |
| GSE28863_A4 | Down | -0.0831470207 |
| GSE48662 | Down | -0.3098423331 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Alpha-Hydroxy-Beta-Phenyl-Propionic Acid | DB02494 | EXPT01733 |
| Omacetaxine mepesuccinate | DB04865 | - |
| Anisomycin | DB07374 | - |
| Puromycin | DB08437 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT031945 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1914-5p | MIMAT0007889 | MIRT035792 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1301-3p | MIMAT0005797 | MIRT035991 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1296-5p | MIMAT0005794 | MIRT036120 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1229-3p | MIMAT0005584 | MIRT036275 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037436 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-671-5p | MIMAT0003880 | MIRT039282 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039771 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040684 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-3p | MIMAT0001340 | MIRT042530 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT046052 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-204-5p | MIMAT0000265 | MIRT047026 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049123 | CLASH//qRT-PCR | Functional MTI (Weak) | 23622248 |
| hsa-let-7c-5p | MIMAT0000064 | MIRT051787 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1260b | MIMAT0015041 | MIRT052681 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
