HCSGD entry for HCN2
1. General information
| Official gene symbol | HCN2 |
|---|---|
| Entrez ID | 610 |
| Gene full name | hyperpolarization activated cyclic nucleotide-gated potassium channel 2 |
| Other gene symbols | BCNG-2 BCNG2 HAC-1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005222 | Intracellular cAMP activated cation channel activity | IDA | molecular_function |
| GO:0005249 | Voltage-gated potassium channel activity | IBA IDA | molecular_function |
| GO:0005272 | Sodium channel activity | IEA | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | IDA | cellular_component |
| GO:0007267 | Cell-cell signaling | TAS | biological_process |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0008076 | Voltage-gated potassium channel complex | TAS | cellular_component |
| GO:0030552 | CAMP binding | IEA | molecular_function |
| GO:0042391 | Regulation of membrane potential | IBA | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0071320 | Cellular response to cAMP | IDA | biological_process |
| GO:0071805 | Potassium ion transmembrane transport | IBA IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1861955587 | 0.9144409445 | 0.8418291946 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0323298107 |
| GSE13712_SHEAR | Down | -0.0806694883 |
| GSE13712_STATIC | Down | -0.1600997744 |
| GSE19018 | Up | 0.1558212504 |
| GSE19899_A1 | Up | 0.0979144746 |
| GSE19899_A2 | Up | 0.3999274900 |
| PubMed_21979375_A1 | Down | -0.0202061076 |
| PubMed_21979375_A2 | Up | 0.4124457216 |
| GSE35957 | Up | 0.1714981265 |
| GSE36640 | Up | 0.0665114163 |
| GSE54402 | Up | 0.0018658242 |
| GSE9593 | Up | 0.2574935775 |
| GSE43922 | Up | 0.4027868450 |
| GSE24585 | Up | 0.0507462357 |
| GSE37065 | Down | -0.1407708330 |
| GSE28863_A1 | Down | -0.0974753012 |
| GSE28863_A2 | Down | -0.3316543083 |
| GSE28863_A3 | Up | 0.3948821649 |
| GSE28863_A4 | Up | 0.0566975352 |
| GSE48662 | Up | 0.2261453511 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Cyclic Guanosine Monophosphate | DB02315 | EXPT02518 | DB04536 |
| Cyclic Adenosine Monophosphate | DB02527 | EXPT00959 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-133a-3p | MIMAT0000427 | MIRT001204 | Luciferase reporter assay//Western blot | Functional MTI | 19136465 |
| hsa-miR-133a-3p | MIMAT0000427 | MIRT001204 | qRT-PCR//Luciferase reporter assay//Western blot | Functional MTI | 18458081 |
| hsa-miR-1 | MIMAT0000416 | MIRT001205 | Luciferase reporter assay//Western blot | Functional MTI | 19136465 |
| hsa-miR-1 | MIMAT0000416 | MIRT001205 | qRT-PCR//Luciferase reporter assay//Western blot//Reporter assay;Western blot;qRT-PCR | Functional MTI | 18458081 |
| hsa-miR-133b | MIMAT0000770 | MIRT016693 | Reporter assay | Functional MTI | 18458081 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT023091 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | 1 | hsa-miR-1 | {Western blot}{Western blot} | {underexpression by 2'-O-Me antisense miRNA oligonucleotides}{overexpression by mature miRNA transfection} | 18458081 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
