HCSGD entry for RORA
1. General information
| Official gene symbol | RORA |
|---|---|
| Entrez ID | 6095 |
| Gene full name | RAR-related orphan receptor A |
| Other gene symbols | NR1F1 ROR1 ROR2 ROR3 RZR-ALPHA RZRA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IDA IEA | molecular_function |
| GO:0003707 | Steroid hormone receptor activity | IEA | molecular_function |
| GO:0004879 | Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0006809 | Nitric oxide biosynthetic process | IEA | biological_process |
| GO:0007165 | Signal transduction | NAS | biological_process |
| GO:0007623 | Circadian rhythm | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0021702 | Cerebellar Purkinje cell differentiation | IEA | biological_process |
| GO:0030522 | Intracellular receptor signaling pathway | TAS | biological_process |
| GO:0043030 | Regulation of macrophage activation | IEA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0046068 | CGMP metabolic process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0022843965 | 0.9168980510 | 0.1279310638 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2669647122 |
| GSE13712_SHEAR | Down | -0.2502517847 |
| GSE13712_STATIC | Down | -0.2176738366 |
| GSE19018 | Up | 0.9081250514 |
| GSE19899_A1 | Up | 0.1307753616 |
| GSE19899_A2 | Up | 0.8944962390 |
| PubMed_21979375_A1 | Up | 2.0595601263 |
| PubMed_21979375_A2 | Up | 1.5109260027 |
| GSE35957 | Down | -0.4101443155 |
| GSE36640 | Up | 0.6190969808 |
| GSE54402 | Up | 0.1898424019 |
| GSE9593 | Up | 0.2991100954 |
| GSE43922 | Up | 0.9767831744 |
| GSE24585 | Down | -0.2385970767 |
| GSE37065 | Up | 0.7619179040 |
| GSE28863_A1 | Up | 0.4814170732 |
| GSE28863_A2 | Up | 1.4854422593 |
| GSE28863_A3 | Up | 0.0925202191 |
| GSE28863_A4 | Down | -0.2980720792 |
| GSE48662 | Up | 0.6355576255 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017642 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT020475 | Microarray | Functional MTI (Weak) | 17242205 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT048959 | CLASH//qRT-PCR | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26361874 | The key nuclear receptors and transcription factors REV-ERBalpha and RORalpha regulate Bmal1 expression and provide stability to the oscillator |
| 26361874 | Environmental agents and redox modulation may alter the levels of REV-ERBalpha and RORalpha in lung tissue in association with a heightened DNA damage response, cellular senescence, and inflammation |
| 26199639 | Bavachalcone Enhances RORalpha Expression, Controls Bmal1 Circadian Transcription, and Depresses Cellular Senescence in Human Endothelial Cells |
| 26199639 | RAR-related orphan receptor alpha (RORalpha), an orphan nuclear receptor, is involved in circadian rhythm regulation, including regulation of cardiovascular function |
| 26199639 | These inhibitory effects were partially reversed by the RORalpha inhibitor VPR-66 |
| 25938935 | Similarly, the levels of the nuclear receptor REV-ERBalpha and retinoic acid receptor-related orphan receptor alpha (ROR alpha), critical regulators of Bmal1 expression, are altered by environmental stresses |
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