HCSGD entry for ROCK1

1. General information

Official gene symbolROCK1
Entrez ID6093
Gene full nameRho-associated, coiled-coil containing protein kinase 1
Other gene symbolsP160ROCK ROCK-I
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneIEAcellular_component
GO:0001726RuffleISScellular_component
GO:0003383Apical constrictionIEAbiological_process
GO:0004672Protein kinase activityTASmolecular_function
GO:0004674Protein serine/threonine kinase activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005814CentrioleIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005856CytoskeletonISScellular_component
GO:0005886Plasma membraneISScellular_component
GO:0006468Protein phosphorylationTASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006921Cellular component disassembly involved in execution phase of apoptosisTASbiological_process
GO:0006939Smooth muscle contractionTASbiological_process
GO:0007159Leukocyte cell-cell adhesionIDAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007266Rho protein signal transductionTASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0016525Negative regulation of angiogenesisIMPbiological_process
GO:0017048Rho GTPase bindingIEAmolecular_function
GO:0022614Membrane to membrane dockingIDAbiological_process
GO:0030027LamellipodiumISScellular_component
GO:0030036Actin cytoskeleton organizationIEAbiological_process
GO:0030155Regulation of cell adhesionTASbiological_process
GO:0032059BlebIEAcellular_component
GO:0032060Bleb assemblyIEAbiological_process
GO:0032956Regulation of actin cytoskeleton organizationTASbiological_process
GO:0043524Negative regulation of neuron apoptotic processIEAbiological_process
GO:0045616Regulation of keratinocyte differentiationIMPbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0050900Leukocyte migrationIDAbiological_process
GO:0050901Leukocyte tethering or rollingIDAbiological_process
GO:0051451Myoblast migrationISSbiological_process
GO:0051492Regulation of stress fiber assemblyTASbiological_process
GO:0051893Regulation of focal adhesion assemblyTASbiological_process
GO:0051894Positive regulation of focal adhesion assemblyISSbiological_process
GO:2000114Regulation of establishment of cell polarityTASbiological_process
GO:2000145Regulation of cell motilityTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.79648984840.33349373120.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0571127878
GSE13712_SHEARUp0.1499338596
GSE13712_STATICUp0.0184544067
GSE19018Down-0.0623394194
GSE19899_A1Down-0.0185952396
GSE19899_A2Down-0.1640737810
PubMed_21979375_A1Down-0.1199317222
PubMed_21979375_A2Down-0.2957065274
GSE35957Up0.1038006688
GSE36640Up0.0979344417
GSE54402Down-0.0548395447
GSE9593Up0.0717198683
GSE43922Down-0.3403188247
GSE24585Down-0.1987419315
GSE37065Down-0.0003192536
GSE28863_A1Up0.1541769943
GSE28863_A2Up0.4314748379
GSE28863_A3Down-0.5469200119
GSE28863_A4Up0.2292835849
GSE48662Down-0.0568766740

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

HYDROXYFASUDILDB04707 -
(S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINEDB07876 -
5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINEDB08162 -
(R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDEDB08756 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-146a-5pMIMAT0000449MIRT000945flow//Western blot//Northern blot//Luciferase reporter assayFunctional MTI18174313
hsa-miR-584-5pMIMAT0003249MIRT004047Immunohistochemistry//Luciferase reporter assay//Microarray//qRT-PCR//Western blotFunctional MTI21119662
hsa-miR-148b-3pMIMAT0000759MIRT007315Western blotFunctional MTI23238785
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26765561Rho-associated kinases 1 and 2 (ROCK1/2) are Rho-GTPase effectors that control key aspects of the actin cytoskeleton, but their role in proliferation and cancer initiation or progression is not known
26765561Here, we provide evidence that ROCK1 and ROCK2 act redundantly to maintain actomyosin contractility and cell proliferation and that their loss leads to cell-cycle arrest and cellular senescence
26765561Accordingly, while the loss of either Rock1 or Rock2 had no negative impact on tumorigenesis in mouse models of non-small cell lung cancer and melanoma, loss of both blocked tumor formation, as no tumors arise in which both Rock1 and Rock2 have been genetically deleted
25460182Recently, it has been reported that Rho-associated coiled-coil protein kinase 1 (ROCK1) might be a key player in TSPC aging process
25460182In this study, whether miRNAs modulate senescence of TSPCs through targeting ROCK1 was evaluated
25460182We found that miR-135a, which directly binds to the 3'-untranslated region of ROCK1, is significantly downregulated in aged compared with young TSPCs
25460182Taken together, our data suggest that miR-135a plays an important role in TSPC senescence via targeting ROCK1
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