HCSGD entry for ROBO2
1. General information
| Official gene symbol | ROBO2 |
|---|---|
| Entrez ID | 6092 |
| Gene full name | roundabout, axon guidance receptor, homolog 2 (Drosophila) |
| Other gene symbols | SAX3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001656 | Metanephros development | ISS | biological_process |
| GO:0001657 | Ureteric bud development | IMP | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0007155 | Cell adhesion | IEA | biological_process |
| GO:0007156 | Homophilic cell adhesion | IDA | biological_process |
| GO:0007165 | Signal transduction | ISS NAS | biological_process |
| GO:0007411 | Axon guidance | ISS TAS | biological_process |
| GO:0007417 | Central nervous system development | NAS | biological_process |
| GO:0007420 | Brain development | IEP | biological_process |
| GO:0008046 | Axon guidance receptor activity | ISS NAS | molecular_function |
| GO:0009986 | Cell surface | IDA | cellular_component |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016199 | Axon midline choice point recognition | ISS | biological_process |
| GO:0021891 | Olfactory bulb interneuron development | ISS | biological_process |
| GO:0030673 | Axolemma | ISS | cellular_component |
| GO:0031290 | Retinal ganglion cell axon guidance | ISS | biological_process |
| GO:0032870 | Cellular response to hormone stimulus | IEP | biological_process |
| GO:0042802 | Identical protein binding | IDA | molecular_function |
| GO:0046982 | Protein heterodimerization activity | IEA | molecular_function |
| GO:0050772 | Positive regulation of axonogenesis | IDA | biological_process |
| GO:0050925 | Negative regulation of negative chemotaxis | IDA | biological_process |
| GO:0051964 | Negative regulation of synapse assembly | ISS | biological_process |
| GO:0061364 | Apoptotic process involved in luteolysis | IEP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4881657156 | 0.0160099654 | 0.9999902473 | 0.2465391228 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0330805407 |
| GSE13712_SHEAR | Up | 0.0252690674 |
| GSE13712_STATIC | Up | 0.0754011977 |
| GSE19018 | Down | -0.2240666283 |
| GSE19899_A1 | Down | -0.1777903981 |
| GSE19899_A2 | Down | -1.1376922733 |
| PubMed_21979375_A1 | Down | -1.1777843012 |
| PubMed_21979375_A2 | Down | -1.3643541917 |
| GSE35957 | Up | 0.9231122721 |
| GSE36640 | Up | 0.8596524824 |
| GSE54402 | Down | -1.2078090075 |
| GSE9593 | Up | 0.0518137003 |
| GSE43922 | Down | -1.6251979149 |
| GSE24585 | Down | -0.6971597162 |
| GSE37065 | Down | -0.1137426923 |
| GSE28863_A1 | Down | -0.2747014381 |
| GSE28863_A2 | Up | 1.1963206605 |
| GSE28863_A3 | Up | 0.0517558461 |
| GSE28863_A4 | Up | 0.2222064822 |
| GSE48662 | Up | 0.0041540548 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-145-5p | MIMAT0000437 | MIRT005809 | In situ hybridization//Luciferase reporter assay//qRT-PCR//western blot//Reporter assay | Functional MTI | 21276775 |
| hsa-miR-342-5p | MIMAT0004694 | MIRT038206 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25241737 | SLIT/ROBO2 signaling promotes mammary stem cell senescence by inhibiting Wnt signaling |
| 25241737 | Here, we demonstrate that SLIT2 restricts stem cell renewal by signaling through ROBO2 in a subset of basal cells to negatively regulate WNT signaling |
| 25241737 | The absence of SLIT/ROBO2 signaling leads to increased levels of nuclear beta-catenin |
| 25241737 | Robo2 loss does not increase the number of stem cells; instead, stem cell renewal is enhanced in the absence of SLIT/ROBO2 signaling |
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