HCSGD entry for RNF6
1. General information
| Official gene symbol | RNF6 |
|---|---|
| Entrez ID | 6049 |
| Gene full name | ring finger protein (C3H2C3 type) 6 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0004842 | Ubiquitin-protein ligase activity | IMP | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006355 | Regulation of transcription, DNA-templated | IMP | biological_process |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | ISS | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0016605 | PML body | IEA | cellular_component |
| GO:0030424 | Axon | ISS | cellular_component |
| GO:0030517 | Negative regulation of axon extension | ISS | biological_process |
| GO:0044314 | Protein K27-linked ubiquitination | IDA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IMP | biological_process |
| GO:0050681 | Androgen receptor binding | IPI | molecular_function |
| GO:0060765 | Regulation of androgen receptor signaling pathway | IMP | biological_process |
| GO:0070936 | Protein K48-linked ubiquitination | ISS | biological_process |
| GO:0085020 | Protein K6-linked ubiquitination | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1016787508 | 0.9714194711 | 0.6639261722 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3179063725 |
| GSE13712_SHEAR | Up | 0.0472991527 |
| GSE13712_STATIC | Up | 0.1436810945 |
| GSE19018 | Down | -0.0856963008 |
| GSE19899_A1 | Up | 0.1661158313 |
| GSE19899_A2 | Up | 0.4032755054 |
| PubMed_21979375_A1 | Up | 0.6905854943 |
| PubMed_21979375_A2 | Down | -0.0699185287 |
| GSE35957 | Up | 0.1614852208 |
| GSE36640 | Up | 0.4408545240 |
| GSE54402 | Up | 0.1253887647 |
| GSE9593 | Up | 0.2885361149 |
| GSE43922 | Up | 0.1948779603 |
| GSE24585 | Up | 0.0407979440 |
| GSE37065 | Down | -0.0625165345 |
| GSE28863_A1 | Up | 0.0313020350 |
| GSE28863_A2 | Up | 0.0105572525 |
| GSE28863_A3 | Down | -0.0604463405 |
| GSE28863_A4 | Up | 0.1048902275 |
| GSE48662 | Down | -0.0639292404 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-186-5p | MIMAT0000456 | MIRT021102 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024905 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026154 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029039 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-296-3p | MIMAT0004679 | MIRT038456 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
