HCSGD entry for RNF5
1. General information
| Official gene symbol | RNF5 |
|---|---|
| Entrez ID | 6048 |
| Gene full name | ring finger protein 5, E3 ubiquitin protein ligase |
| Other gene symbols | RING5 RMA1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004842 | Ubiquitin-protein ligase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005789 | Endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0031966 | Mitochondrial membrane | IEA | cellular_component |
| GO:0044257 | Cellular protein catabolic process | IMP | biological_process |
| GO:0070534 | Protein K63-linked ubiquitination | IDA | biological_process |
| GO:0070936 | Protein K48-linked ubiquitination | IDA | biological_process |
| GO:0071712 | ER-associated misfolded protein catabolic process | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5777312374 | 0.7817352152 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0783723638 |
| GSE13712_SHEAR | Down | -0.1249506017 |
| GSE13712_STATIC | Down | -0.2319144912 |
| GSE19018 | Up | 0.2474168131 |
| GSE19899_A1 | Down | -0.0245384127 |
| GSE19899_A2 | Up | 0.0987297704 |
| PubMed_21979375_A1 | Up | 0.1112976011 |
| PubMed_21979375_A2 | Up | 0.0369333382 |
| GSE35957 | Up | 0.1042673325 |
| GSE36640 | Up | 0.0509932751 |
| GSE54402 | Down | -0.0303983934 |
| GSE9593 | Down | -0.0351621764 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Up | 0.3136167325 |
| GSE28863_A2 | Down | -0.0884702096 |
| GSE28863_A3 | Up | 0.1450272922 |
| GSE28863_A4 | Down | -0.0636994422 |
| GSE48662 | Up | 0.2198254974 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-484 | MIMAT0002174 | MIRT042288 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
