HCSGD entry for RNF4
1. General information
| Official gene symbol | RNF4 |
|---|---|
| Entrez ID | 6047 |
| Gene full name | ring finger protein 4 |
| Other gene symbols | SLX5 SNURF |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | ISS | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | TAS | molecular_function |
| GO:0003713 | Transcription coactivator activity | NAS | molecular_function |
| GO:0004842 | Ubiquitin-protein ligase activity | ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0008134 | Transcription factor binding | IEA | molecular_function |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0015630 | Microtubule cytoskeleton | IDA | cellular_component |
| GO:0016605 | PML body | IDA | cellular_component |
| GO:0030521 | Androgen receptor signaling pathway | NAS | biological_process |
| GO:0031491 | Nucleosome binding | ISS | molecular_function |
| GO:0032184 | SUMO polymer binding | ISS | molecular_function |
| GO:0043161 | Proteasome-mediated ubiquitin-dependent protein catabolic process | IMP | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | ISS | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0046685 | Response to arsenic-containing substance | IDA | biological_process |
| GO:0050681 | Androgen receptor binding | NAS | molecular_function |
| GO:0051865 | Protein autoubiquitination | ISS | biological_process |
| GO:0070534 | Protein K63-linked ubiquitination | ISS | biological_process |
| GO:0070936 | Protein K48-linked ubiquitination | ISS | biological_process |
| GO:0070979 | Protein K11-linked ubiquitination | ISS | biological_process |
| GO:0085020 | Protein K6-linked ubiquitination | ISS | biological_process |
| GO:0090169 | Regulation of spindle assembly | IMP | biological_process |
| GO:0090234 | Regulation of kinetochore assembly | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0730217203 | 0.8892634740 | 0.5760121521 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0331857396 |
| GSE13712_SHEAR | Down | -0.1549869336 |
| GSE13712_STATIC | Up | 0.0374990928 |
| GSE19018 | Down | -0.4232101136 |
| GSE19899_A1 | Up | 0.4271006217 |
| GSE19899_A2 | Up | 0.6240118892 |
| PubMed_21979375_A1 | Up | 1.0452192612 |
| PubMed_21979375_A2 | Up | 1.1909945553 |
| GSE35957 | Down | -0.2121839896 |
| GSE36640 | Down | -0.2525265944 |
| GSE54402 | Up | 0.4818866757 |
| GSE9593 | Up | 0.2988204987 |
| GSE43922 | Up | 0.2241080961 |
| GSE24585 | Up | 0.0237182816 |
| GSE37065 | Down | -0.0101251348 |
| GSE28863_A1 | Up | 0.0108598152 |
| GSE28863_A2 | Up | 0.1003617307 |
| GSE28863_A3 | Up | 0.2741875747 |
| GSE28863_A4 | Up | 0.0856918057 |
| GSE48662 | Down | -0.4452249907 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-361-5p | MIMAT0000703 | MIRT020102 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT024183 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-769-3p | MIMAT0003887 | MIRT039131 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18b-5p | MIMAT0001412 | MIRT042409 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-151a-3p | MIMAT0000757 | MIRT043602 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046803 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-19a-3p | MIMAT0000073 | MIRT050642 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-5p | MIMAT0000072 | MIRT050699 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
