HCSGD entry for BRD2
1. General information
| Official gene symbol | BRD2 |
|---|---|
| Entrez ID | 6046 |
| Gene full name | bromodomain containing 2 |
| Other gene symbols | D6S113E FSH FSRG1 NAT RING3 RNF3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003682 | Chromatin binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006334 | Nucleosome assembly | IMP | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0007283 | Spermatogenesis | TAS | biological_process |
| GO:0016568 | Chromatin modification | IEA | biological_process |
| GO:0070577 | Histone acetyl-lysine binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0516702899 | 0.7989003533 | 0.4981318332 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0948680584 |
| GSE13712_SHEAR | Up | 0.1814037618 |
| GSE13712_STATIC | Down | -0.2160836443 |
| GSE19018 | Down | -0.2358386708 |
| GSE19899_A1 | Down | -0.0785960765 |
| GSE19899_A2 | Up | 0.3811318265 |
| PubMed_21979375_A1 | Up | 1.0479603523 |
| PubMed_21979375_A2 | Up | 0.8473505167 |
| GSE35957 | Down | -0.3746018895 |
| GSE36640 | Up | 0.0979614653 |
| GSE54402 | Down | -0.0563280502 |
| GSE9593 | Up | 0.0529590176 |
| GSE43922 | Up | 0.3631490927 |
| GSE24585 | Up | 0.1963916866 |
| GSE37065 | Up | 0.0844751457 |
| GSE28863_A1 | Up | 0.5494410113 |
| GSE28863_A2 | Up | 0.6106309962 |
| GSE28863_A3 | Up | 0.1031005042 |
| GSE28863_A4 | Down | -0.2510492182 |
| GSE48662 | Up | 0.0753987580 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1229-3p | MIMAT0005584 | MIRT036359 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-940 | MIMAT0004983 | MIRT036599 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-877-5p | MIMAT0004949 | MIRT037308 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-505-5p | MIMAT0004776 | MIRT037955 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-296-3p | MIMAT0004679 | MIRT038361 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-769-3p | MIMAT0003887 | MIRT039079 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039679 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-504-5p | MIMAT0002875 | MIRT041086 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042162 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-204-5p | MIMAT0000265 | MIRT047023 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049226 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7c-5p | MIMAT0000064 | MIRT051807 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052027 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26694612 | COCs expanded in vitro with FSH or EGF underwent the same changes, whereas those expanded with 8-bromo-adenosine-3',5'-cyclic monophosphate (8-Br-cAMP) maintained integrity for a longer time |
| 12417001 | Marked extension of proliferation of rat Sertoli cells in culture using recombinant human FSH |
| 12417001 | Sertoli cells proliferated at basal levels in Dulbecco's modified Eagle's medium (DMEM)-F12 media alone, and proliferation was stimulated further by addition of recombinant human FSH to the culture media |
| 10993816 | In the Brown Norway rat, serum testosterone levels decrease with aging, accompanied by increases in serum FSH |
| 10811143 | We assessed the ability of thymulin, a zinc-dependent nonapeptide produced by the thymic epithelial cells, to influence the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from dispersed anterior pituitary (AP) cells from young, adult, and senescent female rats |
| 10811143 | Perifusion of young and senescent AP cells with thymulin doses of 10(-6) to 10(-5) M gave a significant stimulatory response for LH but not FSH |
| 10811143 | Coincubation of thymulin with the secretagogue gonadotropin-releasing hormone (GnRH) revealed a synergistic effect on LH release and an additive effect on the release of FSH |
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