HCSGD entry for RNASE1

1. General information

Official gene symbolRNASE1
Entrez ID6035
Gene full nameribonuclease, RNase A family, 1 (pancreatic)
Other gene symbolsRIB1 RNS1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003676Nucleic acid bindingIEAmolecular_function
GO:0004522Pancreatic ribonuclease activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0008152Metabolic processTASbiological_process
GO:0016892Endoribonuclease activity, producing 3'-phosphomonoestersIEAmolecular_function
GO:0090305Nucleic acid phosphodiester bond hydrolysisTASbiological_process
GO:0090501RNA phosphodiester bond hydrolysisTASbiological_process
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolyticTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.77953659820.30948234110.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0272056318
GSE13712_SHEARDown-0.8995449324
GSE13712_STATICDown-0.6174363768
GSE19018Up0.1418511091
GSE19899_A1Down-0.0316463449
GSE19899_A2Up0.1267475135
PubMed_21979375_A1Up0.1184930001
PubMed_21979375_A2Down-0.0108039450
GSE35957Up0.0650183680
GSE36640Down-0.0083898344
GSE54402Up0.0561059475
GSE9593Down-0.3920047738
GSE43922Up0.1023438793
GSE24585Down-0.0474712973
GSE37065Up0.0811733163
GSE28863_A1Down-0.1412541339
GSE28863_A2Down-0.0929659234
GSE28863_A3Up0.4423927949
GSE28863_A4Down-0.0509738098
GSE48662Up0.0790290406

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

L-Aspartic AcidDB00128 NUTR00016 | EXPT01823
GuanidineDB00536 APRD01008 | EXPT01546
Adenosine-3'-5'-DiphosphateDB01812 EXPT00370
3'-Phosphate-Adenosine-5'-DiphosphateDB01842 EXPT02498
Formic AcidDB01942 EXPT01461
Cytidine-3'-MonophosphateDB01961 EXPT00809
Adenosine-2'-5'-DiphosphateDB02098 EXPT00366
Isopropyl AlcoholDB02325 EXPT01912 | DB04402
2'-Monophosphoadenosine-5'-DiphosphateDB02363 EXPT00588
2'-Deoxycytidine-2'-Deoxyadenosine-3',5'-MonophosphateDB02573 EXPT00997
3'-UridinemonophosphateDB02714 EXPT03160
Uracil arabinose-3'-phosphateDB02805 EXPT03163
Cysteine-S-AcetamideDB02987 EXPT03271
1-(2-Deoxy-2-Fluoro-3-O-Phosphono-Beta-L-Ribofuranosyl)Pyrimidine-2,4(1h,3h)-DioneDB03155 EXPT03185
U-Pi-a-PiDB03186 EXPT02700
deoxycytidylyl-3',5'-guanosineDB03326 EXPT00901
Uridylyl-2'-5'-Phospho-AdenosineDB03447 EXPT03196
2'-Deoxyuridine 3'-MonophosphateDB03448 EXPT03183
Uridine-2',3'-VanadateDB03512 EXPT03211
Purine Riboside-5'-MonophosphateDB03726 EXPT02482
2'-cytidylic acidDB03765 EXPT00808
5-Amino-1h-Pyrimidine-2,4-DioneDB03792 EXPT03241
2-Methyl-2-PropanolDB03900 EXPT03021
Citric AcidDB04272 EXPT00922
N-FormylmethionineDB04464 EXPT01455
Phosphoric Acid-2'-[2'-Deoxy-Uridine]Ester-5'-Guanosine EsterDB04514 EXPT03158
5'-deoxy-5'-piperidin-1-ylthymidineDB08596 -
1-(2,5-dideoxy-5-pyrrolidin-1-yl-beta-L-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dioneDB08661 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT028796MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.