HCSGD entry for GRK1

1. General information

Official gene symbolGRK1
Entrez ID6011
Gene full nameG protein-coupled receptor kinase 1
Other gene symbolsGPRK1 RHOK RK
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004672Protein kinase activityTASmolecular_function
GO:0004703G-protein coupled receptor kinase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0007601Visual perceptionIEAbiological_process
GO:0007603Phototransduction, visible lightTASbiological_process
GO:0008277Regulation of G-protein coupled receptor protein signaling pathwayTASbiological_process
GO:0008594Photoreceptor cell morphogenesisIEAbiological_process
GO:0016056Rhodopsin mediated signaling pathwayTASbiological_process
GO:0022400Regulation of rhodopsin mediated signaling pathwayIDA TASbiological_process
GO:0038032Termination of G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0042327Positive regulation of phosphorylationIEAbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0046777Protein autophosphorylationIMPbiological_process
GO:0050254Rhodopsin kinase activityIDAmolecular_function
GO:0060060Post-embryonic retina morphogenesis in camera-type eyeIEAbiological_process
GO:0097381Photoreceptor disc membraneTAScellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.91321904940.39236687060.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0462466731
GSE13712_SHEARDown-0.2259180478
GSE13712_STATICDown-0.0439838429
GSE19018Up0.0794067078
GSE19899_A1Down-0.1347587714
GSE19899_A2Down-0.0353759590
PubMed_21979375_A1Down-0.3305862755
PubMed_21979375_A2Down-0.1251369190
GSE35957Down-0.1632855101
GSE36640Down-0.1649920815
GSE54402Down-0.0314135459
GSE9593Up0.2032017507
GSE43922Up0.0432799872
GSE24585Up0.1165344302
GSE37065Down-0.1285571012
GSE28863_A1Down-0.0251575737
GSE28863_A2Up0.0327408237
GSE28863_A3Up0.1574198525
GSE28863_A4Up0.0044149447
GSE48662Down-0.0596631032

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.