HCSGD entry for ACTB
1. General information
| Official gene symbol | ACTB |
|---|---|
| Entrez ID | 60 |
| Gene full name | actin, beta |
| Other gene symbols | BRWS1 PS1TP5BP1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005200 | Structural constituent of cytoskeleton | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IEA TAS | cellular_component |
| GO:0005829 | Cytosol | IEA TAS | cellular_component |
| GO:0005856 | Cytoskeleton | IEA TAS | cellular_component |
| GO:0006457 | Protein folding | TAS | biological_process |
| GO:0006928 | Cellular component movement | TAS | biological_process |
| GO:0007409 | Axonogenesis | IEA | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0014069 | Postsynaptic density | IEA | cellular_component |
| GO:0019894 | Kinesin binding | IPI | molecular_function |
| GO:0019901 | Protein kinase binding | IEA | molecular_function |
| GO:0030424 | Axon | IEA | cellular_component |
| GO:0030529 | Ribonucleoprotein complex | IDA | cellular_component |
| GO:0030863 | Cortical cytoskeleton | IEA | cellular_component |
| GO:0030957 | Tat protein binding | IPI | molecular_function |
| GO:0034329 | Cell junction assembly | TAS | biological_process |
| GO:0034332 | Adherens junction organization | TAS | biological_process |
| GO:0035267 | NuA4 histone acetyltransferase complex | IDA | cellular_component |
| GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | TAS | biological_process |
| GO:0043234 | Protein complex | IEA | cellular_component |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0045216 | Cell-cell junction organization | TAS | biological_process |
| GO:0050998 | Nitric-oxide synthase binding | IPI | molecular_function |
| GO:0051084 | 'de novo' posttranslational protein folding | TAS | biological_process |
| GO:0070062 | Extracellular vesicular exosome | IDA | cellular_component |
| GO:0070688 | MLL5-L complex | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9733566278 | 0.2062679875 | 0.9999902473 | 0.8810078482 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0716395868 |
| GSE13712_SHEAR | Down | -0.0619388049 |
| GSE13712_STATIC | Down | -0.0661581292 |
| GSE19018 | Up | 0.0353437642 |
| GSE19899_A1 | Down | -0.2318486894 |
| GSE19899_A2 | Down | -0.1714087398 |
| PubMed_21979375_A1 | Down | -0.2432572734 |
| PubMed_21979375_A2 | Down | -0.0870494495 |
| GSE35957 | Up | 0.0074215540 |
| GSE36640 | Down | -0.0508397999 |
| GSE54402 | Down | -0.0166911052 |
| GSE9593 | Down | -0.0879374175 |
| GSE43922 | Down | -0.1705155938 |
| GSE24585 | Down | -0.1987565973 |
| GSE37065 | Down | -0.2128939171 |
| GSE28863_A1 | Up | 0.1718393661 |
| GSE28863_A2 | Up | 0.1502187097 |
| GSE28863_A3 | Up | 0.1205891068 |
| GSE28863_A4 | Down | -0.1452214196 |
| GSE48662 | Down | -0.1574347068 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-644a | MIMAT0003314 | MIRT007163 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 23091630 |
| hsa-miR-1 | MIMAT0000416 | MIRT024098 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1307-3p | MIMAT0005951 | MIRT035818 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1303 | MIMAT0005891 | MIRT035877 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1295a | MIMAT0005885 | MIRT035901 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037388 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-455-3p | MIMAT0004784 | MIRT037834 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038781 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041669 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043141 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-326 | MIMAT0000756 | MIRT043650 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-378a-3p | MIMAT0000732 | MIRT043906 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044755 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046589 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT046843 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT048244 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048522 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049406 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051251 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7c-5p | MIMAT0000064 | MIRT051732 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT051913 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052403 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-3176 | MIMAT0015053 | MIRT052797 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 8 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23886751 | These proteins included prohibitin 1, protein disulphide isomerase A3, beta actin, profilin, aldo-ketoreductase 1 C2, alpha crystallin B and the annexins A1, A5 and A6 |
| 22916271 | The large number of multiple size and charge isoforms with an altered content that were identified in this study in P7 versus P3, namely the cytoskeleton components beta-actin (7 forms) and vimentin (24 forms), also emphasizes the importance of post-transcriptional modification upon long-term cultivation |
| 22067611 | Also examined were the expression of genes involved in proliferation and mineralization such as human alkaline phosphatase (ALP), beta-actin, collagen 1 (col-1), core binding factor (cbfa-1), dentin matrix protein (DMP-1), dentin sialophosphoprotein (DSPP), GAPDH, hTERT, osteocalcin (OCN), osteopontin (OPN) as well as oncoproteins involved in senescence (p16, p21 and p53) using RT-PCR |
| 9367056 | To test this hypothesis and determine whether the extracellular matrix may serve as a marker, the steady-state levels of human lysyl oxidase, alpha-I type III collagen and beta-actin transcripts were assessed in various cell lines during in vitro passage |
| 8569279 | When sense- or antisense-cyclin D1 cDNA driven by beta-actin promoter was transfected into young TIG-1 cells, the number of appeared colonies from sense-strand transfected cultures was lower than that from antisense-strand-transfected ones |
| 8077291 | In contrast, expression of growth-related genes such as eIF-5A, c-Ha-ras, and beta-actin did not show significant differences between young and old cells after serum stimulation |
| 1716619 | The polymerase chain reaction (PCR) was used to amplify the growth factors (EGF, FGFb, TGFb1, and IL-1 alpha), EGF receptor, and beta actin sequences from each of the cDNA samples |
| 1716619 | The EGF receptor, FGFb, and beta actin mRNAs were present in all eight cDNA samples |
| 2226653 | The level of collagen type I mRNA decreased during cell ageing, while that of beta-actin did not change |
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