HCSGD entry for REV3L
1. General information
| Official gene symbol | REV3L |
|---|---|
| Entrez ID | 5980 |
| Gene full name | REV3-like, polymerase (DNA directed), zeta, catalytic subunit |
| Other gene symbols | POLZ REV3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003887 | DNA-directed DNA polymerase activity | IBA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IBA | cellular_component |
| GO:0005694 | Chromosome | IBA | cellular_component |
| GO:0006261 | DNA-dependent DNA replication | TAS | biological_process |
| GO:0006297 | Nucleotide-excision repair, DNA gap filling | IBA | biological_process |
| GO:0008408 | 3'-5' exonuclease activity | IBA | molecular_function |
| GO:0016035 | Zeta DNA polymerase complex | IDA | cellular_component |
| GO:0019985 | Translesion synthesis | IBA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0051539 | 4 iron, 4 sulfur cluster binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1553651039 | 0.0307089244 | 0.7832763929 | 0.3304536386 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0525123348 |
| GSE13712_SHEAR | Up | 0.6671002291 |
| GSE13712_STATIC | Up | 0.2453914829 |
| GSE19018 | Up | 0.1327373126 |
| GSE19899_A1 | Down | -0.4493452247 |
| GSE19899_A2 | Down | -0.7847256508 |
| PubMed_21979375_A1 | Down | -0.4313304345 |
| PubMed_21979375_A2 | Down | -0.3331284251 |
| GSE35957 | Up | 0.0451716752 |
| GSE36640 | Up | 0.0289810043 |
| GSE54402 | Down | -0.7085379055 |
| GSE9593 | Down | -0.7930727893 |
| GSE43922 | Down | -0.7837893854 |
| GSE24585 | Up | 0.2254155104 |
| GSE37065 | Up | 0.1826494150 |
| GSE28863_A1 | Up | 1.2906343942 |
| GSE28863_A2 | Up | 1.1471814749 |
| GSE28863_A3 | Down | -0.5676356349 |
| GSE28863_A4 | Down | -0.3855185227 |
| GSE48662 | Down | -0.1521873598 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-340-5p | MIMAT0004692 | MIRT019556 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT025031 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT028057 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030718 | Microarray | Functional MTI (Weak) | 18591254 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 11115544 | The error-prone DNA polymerase zeta catalytic subunit (Rev3) gene is ubiquitously expressed in normal and malignant human tissues |
| 11115544 | Mutagenesis induced by UV light and chemical agents in yeast is largely dependent on the function of Rev3, the catalytic subunit of DNA polymerase zeta that carries out translesion DNA synthesis |
| 11115544 | Human and mouse homologues of the yeast Rev3 gene have recently been identified, and inhibition of Rev3 expression in cultured human fibroblasts by Rev3 anti-sense was shown to reduce UV-induced mutagenesis, indicating that Rev3 also plays a crucial role in mutagenesis in mammalian cells |
| 11115544 | A common variant transcript with an insertion of 128-bp between nucleotides +139 and +140 is found in both human and mouse Rev3 cDNAs, but its biological significance has not been defined |
| 11115544 | We also found that the translational efficiency of Rev3 gene is enhanced by the 5' untranslated region that contains a putative stem-loop structure postulated to inhibit the translation |
| 11115544 | Since the human Rev3 gene is localized to chromosome 6q21, a region previously shown to contain genes involved in tumor suppression and cellular senescence, we examined its expression in various normal and malignant tissues |
| 11115544 | Rev3 and its insertion variant transcripts were ubiquitously detected in all 27 normal human tissues studied, with an additional variant species found in tissues with relatively high levels of Rev3 expression |
| 11115544 | Levels of Rev3 transcripts were similar in lung, gastric, colon and renal tumors compared to normal tissue counterparts |
| 11115544 | The data indicate that Rev3 expression is ubiquitous and is not dysregulated in malignancies |
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