HCSGD entry for UPF1
1. General information
| Official gene symbol | UPF1 |
|---|---|
| Entrez ID | 5976 |
| Gene full name | UPF1 regulator of nonsense transcripts homolog (yeast) |
| Other gene symbols | HUPF1 NORF1 RENT1 pNORF1 smg-2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000184 | Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | IDA IMP NAS TAS | biological_process |
| GO:0000785 | Chromatin | IDA | cellular_component |
| GO:0000932 | Cytoplasmic mRNA processing body | IEA | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003682 | Chromatin binding | IDA | molecular_function |
| GO:0003723 | RNA binding | NAS | molecular_function |
| GO:0004004 | ATP-dependent RNA helicase activity | IDA | molecular_function |
| GO:0004386 | Helicase activity | NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | NAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006200 | ATP catabolic process | IDA | biological_process |
| GO:0006260 | DNA replication | IMP | biological_process |
| GO:0006281 | DNA repair | IDA | biological_process |
| GO:0006406 | MRNA export from nucleus | TAS | biological_process |
| GO:0006449 | Regulation of translational termination | IMP NAS | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0009048 | Dosage compensation by inactivation of X chromosome | IEA | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0016071 | MRNA metabolic process | TAS | biological_process |
| GO:0035145 | Exon-exon junction complex | IDA | cellular_component |
| GO:0044530 | Supraspliceosomal complex | IDA | cellular_component |
| GO:0071044 | Histone mRNA catabolic process | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2264385358 | 0.5871708370 | 0.9079416083 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0197105949 |
| GSE13712_SHEAR | Down | -0.2473713332 |
| GSE13712_STATIC | Down | -0.1711351934 |
| GSE19018 | Down | -0.2319316771 |
| GSE19899_A1 | Down | -0.1382389896 |
| GSE19899_A2 | Down | -0.1801577157 |
| PubMed_21979375_A1 | Up | 0.5066303087 |
| PubMed_21979375_A2 | Up | 0.3700173870 |
| GSE35957 | Down | -0.2354821732 |
| GSE36640 | Up | 0.0129771701 |
| GSE54402 | Up | 0.0154689739 |
| GSE9593 | Up | 0.0427479154 |
| GSE43922 | Up | 0.0655274473 |
| GSE24585 | Down | -0.2721925678 |
| GSE37065 | Down | -0.2390215634 |
| GSE28863_A1 | Up | 0.6484921325 |
| GSE28863_A2 | Up | 0.6404261621 |
| GSE28863_A3 | Up | 0.0850120725 |
| GSE28863_A4 | Up | 0.0378204485 |
| GSE48662 | Up | 0.4275152759 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-423-3p | MIMAT0001340 | MIRT042554 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT048857 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
