HCSGD entry for CCND1
1. General information
| Official gene symbol | CCND1 |
|---|---|
| Entrez ID | 595 |
| Gene full name | cyclin D1 |
| Other gene symbols | BCL1 D11S287E PRAD1 U21B31 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | IDA TAS | biological_process |
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000307 | Cyclin-dependent protein kinase holoenzyme complex | IDA | cellular_component |
| GO:0000320 | Re-entry into mitotic cell cycle | IEA | biological_process |
| GO:0001889 | Liver development | IEA | biological_process |
| GO:0001934 | Positive regulation of protein phosphorylation | IDA | biological_process |
| GO:0003714 | Transcription corepressor activity | IDA | molecular_function |
| GO:0004672 | Protein kinase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005622 | Intracellular | IDA | cellular_component |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005923 | Tight junction | IEA | cellular_component |
| GO:0006974 | Cellular response to DNA damage stimulus | IDA | biological_process |
| GO:0007595 | Lactation | IEA | biological_process |
| GO:0008134 | Transcription factor binding | IPI | molecular_function |
| GO:0010039 | Response to iron ion | IEA | biological_process |
| GO:0010165 | Response to X-ray | IEA | biological_process |
| GO:0010243 | Response to organonitrogen compound | IEA | biological_process |
| GO:0010971 | Positive regulation of G2/M transition of mitotic cell cycle | IDA | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0016538 | Cyclin-dependent protein serine/threonine kinase regulator activity | IEA | molecular_function |
| GO:0017053 | Transcriptional repressor complex | IDA | cellular_component |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0030178 | Negative regulation of Wnt signaling pathway | IEA | biological_process |
| GO:0030857 | Negative regulation of epithelial cell differentiation | IEA | biological_process |
| GO:0030968 | Endoplasmic reticulum unfolded protein response | IEA | biological_process |
| GO:0031100 | Organ regeneration | IEA | biological_process |
| GO:0031571 | Mitotic G1 DNA damage checkpoint | IDA | biological_process |
| GO:0032026 | Response to magnesium ion | IEA | biological_process |
| GO:0032403 | Protein complex binding | IEA | molecular_function |
| GO:0033197 | Response to vitamin E | IEA | biological_process |
| GO:0033327 | Leydig cell differentiation | IEA | biological_process |
| GO:0033598 | Mammary gland epithelial cell proliferation | IEA | biological_process |
| GO:0033601 | Positive regulation of mammary gland epithelial cell proliferation | IEA | biological_process |
| GO:0042493 | Response to drug | IEP | biological_process |
| GO:0042826 | Histone deacetylase binding | IPI | molecular_function |
| GO:0043627 | Response to estrogen | IEA | biological_process |
| GO:0045444 | Fat cell differentiation | IEA | biological_process |
| GO:0045471 | Response to ethanol | IEA | biological_process |
| GO:0045737 | Positive regulation of cyclin-dependent protein kinase activity | IDA | biological_process |
| GO:0051301 | Cell division | IEA | biological_process |
| GO:0051412 | Response to corticosterone | IEA | biological_process |
| GO:0051592 | Response to calcium ion | IEA | biological_process |
| GO:0060070 | Canonical Wnt signaling pathway | IEA | biological_process |
| GO:0060749 | Mammary gland alveolus development | IEA | biological_process |
| GO:0070064 | Proline-rich region binding | IDA | molecular_function |
| GO:0070141 | Response to UV-A | IDA | biological_process |
| GO:0071157 | Negative regulation of cell cycle arrest | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0008779568 | 0.7657078189 | 0.0816242105 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.8638739495 |
| GSE13712_SHEAR | Up | 1.5364038772 |
| GSE13712_STATIC | Up | 1.0463459815 |
| GSE19018 | Up | 0.4838701719 |
| GSE19899_A1 | Up | 0.2723443359 |
| GSE19899_A2 | Up | 0.8551547090 |
| PubMed_21979375_A1 | Down | -0.4951951958 |
| PubMed_21979375_A2 | Up | 0.2964268899 |
| GSE35957 | Up | 1.0218583076 |
| GSE36640 | Up | 1.6226453935 |
| GSE54402 | Up | 0.0760159094 |
| GSE9593 | Up | 1.9294161485 |
| GSE43922 | Up | 0.0047872095 |
| GSE24585 | Down | -1.6726612622 |
| GSE37065 | Up | 0.2105429269 |
| GSE28863_A1 | Down | -0.5096893677 |
| GSE28863_A2 | Up | 0.8809186223 |
| GSE28863_A3 | Up | 0.2927878537 |
| GSE28863_A4 | Up | 0.1462260254 |
| GSE48662 | Up | 0.4248119330 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-20a-5p | MIMAT0000075 | MIRT000179 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 18695042 |
| hsa-miR-20a-5p | MIMAT0000075 | MIRT000179 | Luciferase reporter assay | Functional MTI | 21283765 |
| hsa-miR-195-5p | MIMAT0000461 | MIRT000225 | Luciferase reporter assay//Western blot | Functional MTI | 22217655 |
| hsa-miR-195-5p | MIMAT0000461 | MIRT000225 | Luciferase reporter assay | Functional MTI | 23383003 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT000480 | qRT-PCR//Luciferase reporter assay//Western blot//Microarray//Reporter assay;Western blot;qRT-PCR;Microarray;Other | Functional MTI | 20304954 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT000480 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20655737 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT000480 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-424-5p | MIMAT0001341 | MIRT000941 | qRT-PCR//flow//Luciferase reporter assay//Western blot | Functional MTI | 18701644 |
| hsa-miR-424-5p | MIMAT0001341 | MIRT000941 | Luciferase reporter assay | Functional MTI | 19956200 |
| hsa-miR-16-1-3p | MIMAT0004489 | MIRT000957 | qRT-PCR//GFP reporter assay//Western blot | Functional MTI | 18483394 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT001013 | qRT-PCR//Luciferase reporter assay//Western blot//Reporter assay | Functional MTI | 18406353 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT001013 | Luciferase reporter assay | Functional MTI | 19461653 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT001013 | qRT-PCR//Western blot | Functional MTI | 20309880 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT001013 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-520b | MIMAT0002843 | MIRT006283 | Luciferase reporter assay | Functional MTI | 22319632 |
| hsa-miR-503-5p | MIMAT0002874 | MIRT001105 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 19538740 |
| hsa-miR-503-5p | MIMAT0002874 | MIRT001105 | Luciferase reporter assay | Functional MTI | 19956200 |
| hsa-miR-19b-1-5p | MIMAT0004491 | MIRT006276 | Western blot | Functional MTI | 22197821 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT001225 | Western blot//Luciferase reporter assay | Functional MTI | 18483394 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT001225 | qRT-PCR//Luciferase reporter assay//Western blot | Functional MTI | 19591824 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT001225 | qRT-PCR//flow//Western blot//Luciferase reporter assay | Functional MTI | 18701644 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT001225 | Luciferase reporter assay | Functional MTI | 18931683 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT001225 | Luciferase reporter assay | Functional MTI | 19549910 |
| hsa-miR-15a-5p | MIMAT0000068 | MIRT001227 | qRT-PCR//Luciferase reporter assay//Western blot | Functional MTI | 19591824 |
| hsa-miR-15a-5p | MIMAT0000068 | MIRT001227 | Luciferase reporter assay | Functional MTI | 19549910 |
| hsa-miR-15a-5p | MIMAT0000068 | MIRT001227 | Luciferase reporter assay | Functional MTI | 18931683 |
| hsa-miR-15a-5p | MIMAT0000068 | MIRT001227 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-365a-3p | MIMAT0000710 | MIRT006242 | Luciferase reporter assay//Western blot | Functional MTI | 22072615 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT002484 | Immunoblot//Immunofluorescence//Luciferase reporter assay//qRT-PCR//Reporter assay;Other | Functional MTI | 18379589 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT002484 | immunoblot//Luciferase reporter assay//Northern blot//Western blot | Functional MTI | 20133835 |
| hsa-miR-19a-3p | MIMAT0000073 | MIRT003426 | flow//Luciferase reporter assay//Microarray//qRT-PCR//Western blot | Functional MTI | 20133739 |
| hsa-miR-302a-3p | MIMAT0000684 | MIRT003637 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 18710938 |
| hsa-miR-302a-3p | MIMAT0000684 | MIRT003637 | Luciferase reporter assay//Microarray//Northern blot//Western blot | Functional MTI | 21062975 |
| hsa-miR-15b-5p | MIMAT0000417 | MIRT003913 | qRT-PCR//Western blot | Non-Functional MTI | 19135980 |
| hsa-miR-449a | MIMAT0001541 | MIRT004679 | Flow//Immunoblot//Luciferase reporter assay | Functional MTI | 20948989 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT005287 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 18695042 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT005287 | Luciferase reporter assay | Functional MTI | 21283765 |
| hsa-miR-302c-3p | MIMAT0000717 | MIRT005671 | Luciferase reporter assay//Microarray//Northern blot//Western blot | Functional MTI | 21062975 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT005861 | Luciferase reporter assay | Functional MTI | 21283765 |
| hsa-miR-34b-3p | MIMAT0004676 | MIRT006290 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 22113133 |
| hsa-miR-338-3p | MIMAT0000763 | MIRT006822 | Luciferase reporter assay | Functional MTI | 22912826 |
| hsa-miR-9-5p | MIMAT0000441 | MIRT007372 | Luciferase reporter assay | Functional MTI | 23383271 |
| hsa-miR-374b-5p | MIMAT0004955 | MIRT016061 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-425-5p | MIMAT0003393 | MIRT016658 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020946 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1 | MIMAT0000416 | MIRT023800 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT024995 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT028002 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029483 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-let-7f-5p | MIMAT0000067 | MIRT032092 | qRT-PCR | Functional MTI (Weak) | 19956384 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT048256 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049839 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | NA | hsa-let-7b | 18379589 | |||
| hsa-miR-302a-3p | MIMAT0000684 | NA | hsa-miR-302a | {Western blot} | {downregulation by anti-miRNA oligonucleotide} | 18710938 | |
| hsa-miR-16-5p | MIMAT0000069 | 2 | hsa-miR-16 | {Western blot} | {overexpression} | 18701644 | |
| hsa-miR-16-5p | MIMAT0000069 | 1 | hsa-miR-16 | {Western blot} | {overexpression} | 18701644 | |
| hsa-miR-34a-5p | MIMAT0000255 | NA | hsa-miR-34a | {Western blot} | {overexpression by miRNA precursor transfection} | 18834855 | |
| hsa-miR-296-5p | MIMAT0000690 | NA | hsa-miR-296-5p | {Western blot} | {downregulation} | 20485139 | |
| hsa-miR-19a-3p | MIMAT0000073 | NA | hsa-miR-19a | {Western blot} | {overexpression} | 20133739 | |
| hsa-miR-15a-5p | MIMAT0000068 | 2 | hsa-miR-15a | {Western blot} | {overexpression by miRNA precursor transfection} | 19823025 | |
| hsa-miR-15a-5p | MIMAT0000068 | 1 | hsa-miR-15a | {Western blot} | {overexpression by miRNA precursor transfection} | 19823025 | |
| hsa-miR-503-5p | MIMAT0002874 | NA | hsa-miR-503 | {Western blot} | {overexpression by miRNA precursor transfection} | 19538740 | |
| hsa-miR-155-5p | MIMAT0000646 | NA | hsa-miR-155 | 19538740 | |||
| hsa-miR-195-5p | MIMAT0000461 | 2 | hsa-miR-195 | {Western blot} | {overexpression} | 19441017 | |
| hsa-miR-195-5p | MIMAT0000461 | 1 | hsa-miR-195 | {Western blot} | {overexpression} | 19441017 | |
| hsa-miR-302a-3p | MIMAT0000684 | 1 | hsa-miR-302a | {Western blot} | {overexpression by miRNA mimics tranfection} | 21062975 | |
| hsa-miR-302c-3p | MIMAT0000717 | 1 | hsa-miR-302c | {Western blot} | {overexpression by miRNA mimics tranfection} | 21062975 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 70 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27698927 | As with those evidence of senescence in advanced cell passages, expression of p21 and cyclin D1 increased when the expression of beta-catenin and its downstream protein, TCF, declined |
| 26718258 | Also, DhL reduced the expression of the cell cycle proteins cyclin D1 and B1 and the inhibitor of apoptosis protein, survivin |
| 26683595 | Following inhibition of ASPH activity, phosphorylation of glycogen synthase kinase 3beta and p16 expression were increased to promote senescence, whereas cyclin D1 and proliferating cell nuclear antigen were decreased to reduce cell proliferation |
| 26360782 | Furthermore, BK treatment of H2O2-exposed cells leads to elevated phosphorylation of RB, AKT, and cyclin D1 compared with H2O2-treatment alone |
| 26215037 | Western blot was used to assess SHP-1, p21, p53, pRb, Rb, H3K9Me3, HP1gamma, CDK4, cyclin D1, cyclin E, and p16 protein expressions |
| 25693733 | Fucoidan also promoted the expression of cell cycle-associated proteins (cyclin E, Cdk2, cyclin D1, and Cdk4) in senescent ECFCs, significantly reversed cellular senescence, and increased the proliferation of ECFCs via the FAK, Akt, and ERK signaling pathways |
| 25572145 | Re-expression of E2 expression with TNF-alpha treatment resulted in an increase in the expression of anti-apoptotic Bcl2 (B-cell lymphoma 2) protein and other pro-survival genes like cyclin D1 (cyc D1), survivin and hTERT (human telomerase reverse transcriptase) |
| 25351164 | In contrast, self-renewal assays validated that Tnmd KO TSPC exhibit significantly reduced proliferative potential, which was also reflected in lower Cyclin D1 levels |
| 25187009 | In this study, we established nonhuman primate primary cell lines by introducing the genes for CDK4R24C, cyclin D1, and hTERT |
| 25187009 | The present study shows that introduction of the CDK4R24C, cyclin D1, and hTERT genes are effective methods of establishing nonhuman primate cell lines |
| 25132913 | No significant change was observed on the expression of CCND1, SIRT1, and miR-34a upstream transcriptional regulator, TP53 |
| 25077541 | We demonstrate that miR-17 targets both ADCY5 and IRS1, upregulating the downstream signals MKP7, FoxO3, LC3B, and HIF1alpha, and downregulating mTOR, c-myc, cyclin D1, and JNK |
| 24762088 | Mel-Juso cells overexpressing miR-125b were tumourigenic in mice, but the tumours exhibited higher level of cell senescence and decreased expression of proliferation markers, cyclin D1 and Ki67 than the control tumours |
| 24747969 | Decreased cellular proliferation was associated with G0/G1 cell cycle arrest and decrease expression of cell cycle regulatory proteins like cyclin E, cyclin D1 and decrease in BrdU incorporation |
| 24551275 | Cell cycle regulatory proteins Cyclin D1 and SOCS3 were significantly enhanced in AEC within the remodelled fibrotic areas of IPF lungs but expression was negligible in myofibroblasts |
| 24505380 | This was paralleled in old kidneys by a higher number of Cyclin D1 positive tubular cells |
| 24505380 | This finding was corroborated by a positive correlation between Cyclin D1 positivity and age in human renal biopsies |
| 24505380 | Finally, the positive correlation of Cyclin D1 with age and cellular senescence in PTEC needs further evaluation as to a functional role of renal epithelial aging |
| 24036549 | Recently we demonstrated that hyper-induction of cyclin D1 during geroconversion was mostly dependent on MEK, whereas rapamycin only partially inhibited cyclin D1 accumulation |
| 24036549 | Here we show that, while not affecting cyclin D1, siRNA for p70S6K partially prevented loss of RP (replicative/regenerative potential) during p21-induced cell cycle arrest |
| 24036549 | Similarly, an inhibitor of p70 S6 kinase (PF-4708671) partially inhibited phosphorylation of S6 and preserved RP, while only marginally prevented cyclin D1 induction |
| 23852369 | MEK drives cyclin D1 hyperelevation during geroconversion |
| 23852369 | Hyperexpression of cyclin D1 is a universal marker of senescence along with hypertrophy, beta-Gal staining and loss of replicative/regenerative potential (RP), namely, the ability to restart proliferation when the cell cycle is released |
| 23852369 | Inhibition of MTOR decelerates geroconversion, although only partially decreases cyclin D1 |
| 23852369 | Here we show that in p21- and p16-induced senescence, inhibitors of mitogen-activated/extracellular signal-regulated kinase (MEK) (U0126, PD184352 and siRNA) completely prevented cyclin D1 accumulation, making it undetectable |
| 23852369 | In such cells, U0126 by itself induced senescence that was remarkably cyclin D1 negative |
| 23852369 | We confirmed that the inhibitor of CDK4/6 caused cyclin D1 positive senescence in normal RPE cells, whereas U0126 prevented cyclin D1 expression |
| 23852369 | Elimination of cyclin D1 by siRNA did not prevent other markers of senescence that are consistent with the lack of its effect on MTOR |
| 23852369 | Second, hallmarks of senescence may be dissociated, and hyperelevated cyclin D1, a marker of hyperactivation of senescent cells, did not necessarily determine other markers of senescence |
| 23852369 | Third, inhibition of MEK was sufficient to eliminate cyclin D1, regardless of MTOR |
| 23826727 | A downregulation in p16(ink4a) occurs when PTEN is lost as a result of cyclin D1 induction and the activation of E2F transcription factors |
| 23574719 | Furthermore, levels of the G1-specific markers, Cyclin D1 and Caveolin-1, were distinctly increased, while S/G2-specific markers, Cyclin B1 and Aurora A, were significantly downregulated |
| 23472054 | ING1a overexpression inhibits growth; induces a large flattened cell morphology and the expression of senescence-associated beta-galactosidase; increases Rb, p16, and cyclin D1 levels; and results in the accumulation of senescence-associated heterochromatic foci |
| 23383739 | METHODS: After treatment with etoposide, selected biochemical and morphological parameters were examined, including: the activity of senescence-associated ss-galactosidase, SAHF formation, cell cycle progression, the induction of p21Cip1/Waf1/Sdi1 and cyclin D1, DNA strand breaks, the disruption of cell membrane asymmetry/integrity and ultrastructural alterations |
| 23383739 | Also upregulation of cyclin D1 was observed |
| 23187803 | Here we show that geroconversion is accompanied by dramatic accumulation of cyclin D1 followed by cyclin E and replicative stress |
| 23187803 | Also, senescent mouse embryonic fibroblasts (MEFs) overexpressed cyclin D1 |
| 23079655 | Ubiquitous shutdown of cyclin D1 or inhibition of cyclin D-associated kinase activity in mice bearing ErbB2-driven mammary carcinomas triggered tumor cell senescence, without compromising the animals' health |
| 22855034 | At the end of the 48-h culture, the following analyses were performed including determination of senescence-associated beta-galactosidase (SAbeta-Gal) activity, flow cytometry analysis of cell cycle, real-time quantitative reverse transcription polymerase chain reaction (RT-PCR) analyses of p16, Cyclin D1, cyclin-dependent kinase 4 (CDK4) and retinoblastoma (Rb) mRNA expression, and Western blotting analyses of p16, cyclin D1, CDK4 and phosphoretinoblastoma (pRb) protein expressions |
| 22855034 | Compared with the old group, VSMCs in the treated groups had a significant increase in p16 and Rb mRNA expression and a significant decrease in Cyclin D1 and CDK4 mRNA expression (P<0 |
| 22783442 | The expression of cyclin D1, Rb, maspin, p53 and mouse double minute 2 (MDM2) was analyzed in 20 paraffin-embedded tissue samples of normal oral mucosa (NOM), 14 samples of oral leukoplakia without dysplasia (OLD-), 11 samples of leukoplakia with dysplasia (OLD+) and 15 samples of oral squamous cell carcinoma (OSCC) by immunohistochemistry in tissue arrays |
| 22783442 | Cyclin D1 expression was also significantly more frequent in OLD- samples vs |
| 22611193 | Cell cycle quiescence is associated with down-regulation of cyclin D1, up-regulation of the cyclin-dependent kinase inhibitors, p21(cip1 |
| 22467239 | We first observed that AGR2 was overexpressed in Chinese Han PCa tissues and had a positive correlation with cyclin D1 and p-Rb but not with p16(INK4a) |
| 22467239 | The expression of cyclin D1 showed similar pattern to the AGR2 in cell lines |
| 22358238 | The expression levels of ELN, COL1A1, MMP1, CCND1, RB1, and IL6 genes were determined using the quantitative real-time polymerase chain reaction |
| 22358238 | CCND1, RB1, MMP1, and IL6 were upregulated in senescent fibroblasts |
| 22358238 | Incubation with gamma-tocotrienol decreased CCND1 and RB1 expression in senescent fibroblasts, decreased cell populations in the G(0)/G(1) phase and increased cell populations in the G(2)/M phase |
| 22037217 | Molecular analysis revealed enhanced cell proliferation, decreased apoptosis, and increased expression of CCND1 in the basal layer of the head and neck epithelia, as well as in the tumors of Tgfbr1/Pten double conditional knockout (2cKO) mice |
| 25961265 | Furthermore, NaBu down-regulates the proto-oncogenes c-Myc, Cyclin D1 and E2F1 mRNA levels |
| 21788308 | 1), RASSF1A weakly reduces cell proliferation and anchorage-independent growth of uveal melanoma cells without effect on ERK1/2 activation, cyclin D1 and p27(Kip1) expression |
| 21788308 | We showed that siRNA-mediated depletion of RASSF1A increased ERK1/2 activation, cyclin D1 expression, and also decreased p27(Kip1) expression in normal uveal melanocytes |
| 21613412 | Cyclin D1, the regulatory subunit of cyclin-dependent protein kinases four and six (CDK4/6) serves as a convergence point for multiple signaling pathways |
| 21562236 | Western-blot analysis shows that cyclin D1 and phosphorylated retinoblastoma protein were significantly lower in HF/C offspring than in C/C offspring |
| 21515304 | DPV-treated cells showed marked relocalization of Cyclin D1 from nucleus to cytoplasm |
| 21367843 | In this context, cyclin D1 expression and retinoblastoma tumor suppressor protein (RB) phosphorylation are maintained even with efficient ablation of ER with pure antagonists |
| 21289643 | Consistently, coexpression of JunB and Ras induced premature epidermal differentiation concomitant with upregulation of p16 and filaggrin and downregulation of cyclin D1 and cyclin-dependent kinase 4 (CDK4) |
| 21286718 | The combination could also inhibit the expression of Cyclin D1 and phosphorylated mTOR while had no impact on p53, p16, PTEN, and HIF-1alpha |
| 21197417 | An increase in p21 and cyclin D1 expression occurred in EA |
| 21047732 | Paradoxically, G(1)-S phase genes such as MYC, CDK4, CDK6, CCND1, and CCND2 were strongly downregulated, in line with the observed G(1) arrest |
| 20948989 | In silico analysis of 3'UTR regions reveal a putative miR-449a target site in the transcript of Cyclin D1 (CCND1); an oncogene involved in directly regulating Rb activity and cell cycle progression |
| 20948989 | Luciferase 3'UTR reporter constructs and inhibitory oligonucleotides confirm that Cyclin D1 is a direct downstream target of miR-449a |
| 20948989 | We also reveal that miR-449a suppresses Rb phosphorylation through the knockdown of Cyclin D1 and previously validated target HDAC1 |
| 20938386 | Total RNA isolated from these samples was used to measure the gene expression of p16INK4a, RB, cyclin D1, CDK4, PTEN, p27KIP, p19ARF, p21, TERT, and RAGE by real-time polymerase chain reaction assay |
| 20938386 | The increased cyclin D1 mRNA level was statistically significant only at the ninth month following amputation; CDK4 and TERT mRNA levels were downregulated to a similar extent at both points compared with nonamputated controls |
| 20937593 | Reduced expression of cyclin D1, IkappaBalpha, phospho-IkappaBalpha, and IKKbeta occurred in cisplatin- and curcumin-treated cell lines |
| 19723919 | Cox proportional hazard models computed hazard ratio (HR) for death, adjusted for potential confounders, including p53, cyclin D1, KRAS, BRAF, PIK3CA, LINE-1 hypomethylation, CpG island methylator phenotype (CIMP), and microsatellite instability (MSI) |
| 19098430 | In contrast, the levels of cyclin D1, CDK4 and CDK6 were sharply decreased |
| 18948731 | In the presence of serum, induction of p21 caused senescence, characterized by beta-Galactosidase staining, cell hypertrophy, increased levels of cyclin D1 and active TOR (target of rapamycin, also known as mTOR) |
| 18948731 | In normal human cells such as WI38 fibroblasts and retinal pigment epithelial (RPE) cells, serum starvation caused quiescence, which was associated with low levels of cyclin D1, inactive TOR and slim-cell morphology |
| 18852884 | A significant upregulation of cyclin D1 and reduction of cyclin A was detected in HFF-MBPsi-4 as compared to control HFF |
| 18845559 | Coexpression of cyclin D1, but not a dominant-negative p53, rescued proliferation in the Cdx2-expressing cells |
| 18438428 | Cyclin D1 is a key regulator of cell proliferation |
| 18438428 | We used B-lymphoid cell lines producing cyclin D1 to investigate the role of this protein in B-cell lymphomas and leukaemias |
| 18438428 | Constitutive low levels of cyclin D1 had no effect per se on cell proliferation, but conferred resistance to various apoptotic stimuli in B cells |
| 18438428 | Proteomic analysis showed that the presence of cyclin D1 led to intracellular accumulation of various molecular chaperones |
| 18438428 | Thus, constitutive de-novo cyclin D1 production in B cells delays commitment to apoptosis by inducing Hsp70 chaperoning activity on pre- and post-mitochondrial pro-apoptotic factors |
| 18271016 | In this report, we show that depletion of EWS/FLI1 in Ewing's cell lines results in a senescence phenotype, a marked increase in expression of the G1/S regulatory proteins p27(kip1) and p57(kip2), and a significant decrease in cyclin D1 and CDK2 |
| 18056951 | Cyclin D1 overexpression permits the reproducible detection of senescent human vascular smooth muscle cells |
| 18056951 | In particular, we have identified a 12-fold upregulation of expression in the cyclin D1 message, which is reflected in a concomitant upregulation at the protein level |
| 18056951 | Quantitative cytochemical analysis of senescent and growing vascular smooth muscle cells indicates that cyclin D1 reactivity is a considerably better marker of replicative senescence than senescence-associated beta-galactosidase activity |
| 17569615 | These inhibitory effects of IFI16 were associated with upregulation of p21 and inhibition of cyclin E, cyclin D1, c-Myc and Ras |
| 16862142 | PAI-1 knockdown results in sustained activation of the PI(3)K-PKB-GSK3beta pathway and nuclear retention of cyclin D1, consistent with a role for PAI-1 in regulating growth factor signalling |
| 16609829 | All cultures, treated and untreated, were lysed following 24 hr of incubation, and the lysate was used to perform immunoblot analysis for p21, ppRb, and cyclin D1 |
| 16609829 | No differences were observed in cyclin D1 with respect to basal levels in fb-P versus fb-D or in treated versus untreated groups |
| 16456675 | The latter has already been well elucidated; TIS21 inhibits the expression of cyclin D1, thus resulting in the arrest of cells at G1/S phase by pRB and p53 dependent manner |
| 16288019 | Mechanistically, cyclin D1 mRNA levels are not altered in the knockout cells, but protein half-life is markedly increased |
| 16288019 | Using this model, we provide the first direct genetic evidence that dysregulation of PKA promotes important steps in tumorigenesis, and that cyclin D1 is an essential target of PKA |
| 16024017 | Nevertheless, cyclin D1 and D3, which are negatively regulated by CDKIs, were also increased |
| 15111320 | Beta-catenin simultaneously induces activation of the p53-p21WAF1 pathway and overexpression of cyclin D1 during squamous differentiation of endometrial carcinoma cells |
| 15111320 | To clarify roles during squamous differentiation (SqD) of endometrial carcinoma (Em Ca) cells, we investigated expression of beta-catenin, as well as cyclin D1, p53, p21WAF1, and PML (promyelocytic leukemia) in 80 cases of Em Ca with SqD areas, in comparison with cell proliferation determined with reference to Ki-67 antigen positivity |
| 15111320 | In clinical cases, nuclear beta-catenin accumulation was more frequent in SqD areas, being positively linked with expression of cyclin D1, p53, and p21WAF1, and inversely with Ki-67 and PML immunoreactivity |
| 15111320 | Significant correlations of nuclear beta-catenin, cyclin D1, p53, and p21WAF1 were noted between SqD and the surrounding carcinoma lesions |
| 15111320 | The Ishikawa cell line, with stable or tetracycline-regulated expression of mutant beta-catenin, showed an increase in expression levels of cyclin D1, p14ARF, p53, and p21WAF1 but not PML, and activation of beta-catenin-TCF4-mediated transcription determined with TOP/FOP constructs |
| 15111320 | Moreover, overexpressed beta-catenin could activate transcription from p14ARF and cyclin D1 promoters, in a TCF4-dependent manner |
| 13679081 | The cell cycle-associated proteins such as cyclin D1, cyclin E, CDK2, and CDK4, and kinase activities associated with CDK2 and CDK4 were increased in aged MASMC |
| 12533509 | We further demonstrate that mutant cells that escaped senescence had undergone clonal selection for faster proliferation and extensive genetic/molecular alterations, including overexpression of cyclin D1 and cyclin A and loss of p53 |
| 12464605 | A novel transcriptional inhibitory element differentially regulates the cyclin D1 gene in senescent cells |
| 12464605 | In this study, a novel transcriptional regulatory element was identified in the 5'-untranslated region of the cyclin D1 gene |
| 12464605 | We show that this element differentially suppresses cyclin D1 expression in young versus senescent fibroblasts |
| 12464605 | Site-directed mutagenesis within this cyclin D1 inhibitory element (DIE) abolished binding activity and selectively increased cyclin D1 promoter activity in young but not in senescent cells |
| 12464605 | This study provides evidence that loss of transcriptional repressor activity contributes to the up-regulation of cyclin D1, and possibly additional age-regulated genes, during cellular senescence |
| 11642719 | Cyclin D1 positivity was found in some macrophages |
| 10585273 | Complex mechanisms underlying impaired activation of Cdk4 and Cdk2 in replicative senescence: roles of p16, p21, and cyclin D1 |
| 10585273 | Cdk2 protein was dramatically decreased in senescent cells and complexed primarily with cyclin D1 and p21 |
| 10585273 | Thus, one of the underlying molecular events involved in replicative senescence is the impaired activation of Cdk4 and Cdk2 due to increased binding of p16 to Cdk4 and increased association of Cdk2 with cyclin D1 and p21 |
| 9925749 | Cyclin D1 is known as a promoting factor for cell growth |
| 9925749 | We previously showed, however, that the expression of cyclin D1 increases markedly in senescent human fibroblasts in vitro |
| 9925749 | Colony formation after transfection with the cyclin D1 expression vector was repressed in NIH-3T3, TIG-1, CHO-K1, and HeLa cells, compared with those with mock and cyclin E expression vectors |
| 9925749 | A transient transfection assay demonstrated that the overexpression of cyclin D1 inhibited DNA synthesis of TIG-1 cells |
| 9925749 | The complexes of cyclin D1 with PCNA and cdk2 increased remarkably in senescent cells, compared with young counterparts |
| 9925749 | DNA synthesis of NIH-3T3 transfectants with PCNA or cdk2 expression vectors was not inhibited by the overexpression of cyclin D1 |
| 9925749 | These results indicate that an excessive level of cyclin D1 represses cell proliferation by inhibiting DNA replication and cdk2 activity through the binding of cyclin D1 to PCNA and cdk2, as it does in senescent cells |
| 9637785 | The regulation of cyclin D1 expression in senescent human fibroblasts |
| 9637785 | To clarify the molecular mechanisms of cyclin D1 expression during in vitro cellular aging, we investigated the binding of nuclear protein factors to the cyclin D1 gene promoter domain in young and senescent normal human fibroblasts |
| 9637785 | The cyclin D1 promoter binding activities of nuclear protein factors from young and senescent cells were examined by the gel mobility shift assay |
| 8853900 | They also elevate the expression of cyclin D1 after 4 hours of serum treatment |
| 8569279 | Enhanced expression of cyclin D1 in senescent human fibroblasts |
| 8569279 | Exceptionally, the expression level of cyclin D1 in senescent cells was constitutively higher than in young cells and further increased after serum stimulation, which was confirmed by Northern and Western blots and immunoprecipitation |
| 8569279 | However, clones expressing cyclin D1 at low or undetectable level which were isolated after transfection with antisense-cyclin D1 proliferated up to the same division limit as untransfected and sense-strand transfected cells |
| 8569279 | Four clones of SV40-transformed TIG-1 expressed cyclin D1 at moderate levels during their extended proliferative lifespan |
| 8569279 | It appears that, if the extremely overexpressed cyclin D1 could cause an inhibition of cell proliferation at senescent stage, cellular senescence occurs regardless of overexpression of cyclin D1 |
| 7698220 | Overexpression of cyclin D1 blocks proliferation of normal diploid fibroblasts |
| 7698220 | Human cyclin D1 forms complexes with several Cdks, with proliferating cell nuclear antigen, and with a recently discovered 21-kDa inhibitor of Cdk activity |
| 7698220 | Here we report that normal human diploid fibroblasts that endogenously or ectopically express high levels of cyclin D1 are unable to enter S phase in response to normally mitogenic stimuli |
| 7698220 | These observations provide evidence that cyclin D1 is involved with the regulation of cell proliferation by more than one mechanism |
| 8248208 | Surprisingly, we found 10- to 15-fold higher constitutive amounts of both cyclin E and cyclin D1 in senescent cells compared to quiescent early-passage cells |
| 8248208 | We also show that a majority of the Cdk2 in senescent cells, but not in early-passage cells, was complexed with cyclin D1 |
| 8360268 | Both the synthesis and the steady-state level of cyclin D1 protein were also found to be markedly higher in senescent cells (3- to 6-fold) |
| 8360268 | Our data also suggest that the deregulated expression of cyclin D1 and E is not sufficient to drive senescent cells into DNA replication |
| 1409718 | The human CCND1 cyclin D1/PRAD1 gene was previously identified by a genetic screen for G1 cyclin function in Saccharomyces cerevisiae and also was identified as the putative BCL1 oncogene |
| 1409718 | To determine if expression of human D-type cyclin genes correlates with the state of cell growth, we examined the level of mRNAs for CCND1 and a related gene, CCND3, in normal human diploid fibroblasts (HDF) |
| 1409718 | Cycloheximide partially blocks the induction of CCND1 and CCND3 gene expression by serum, suggesting that both de novo protein synthesis-dependent and -independent pathways contribute to induction |
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