HCSGD entry for KLHL12
1. General information
| Official gene symbol | KLHL12 |
|---|---|
| Entrez ID | 59349 |
| Gene full name | kelch-like family member 12 |
| Other gene symbols | C3IP1 DKIR hDKIR |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IMP | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0006513 | Protein monoubiquitination | IDA | biological_process |
| GO:0006888 | ER to Golgi vesicle-mediated transport | IDA | biological_process |
| GO:0016055 | Wnt signaling pathway | IMP | biological_process |
| GO:0030134 | ER to Golgi transport vesicle | IDA | cellular_component |
| GO:0031463 | Cul3-RING ubiquitin ligase complex | IDA | cellular_component |
| GO:0048208 | COPII vesicle coating | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4784188139 | 0.6506469663 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1147786870 |
| GSE13712_SHEAR | Down | -0.1432674641 |
| GSE13712_STATIC | Down | -0.0010099603 |
| GSE19018 | Down | -0.0590124401 |
| GSE19899_A1 | Down | -0.2235787036 |
| GSE19899_A2 | Up | 0.6232334555 |
| PubMed_21979375_A1 | Up | 0.1820324620 |
| PubMed_21979375_A2 | Up | 0.0900734798 |
| GSE35957 | Up | 0.0283180204 |
| GSE36640 | Up | 0.2902999473 |
| GSE54402 | Up | 0.0508493319 |
| GSE9593 | Up | 0.2413997946 |
| GSE43922 | Up | 0.0348674133 |
| GSE24585 | Up | 0.4761837248 |
| GSE37065 | Up | 0.0141621103 |
| GSE28863_A1 | Down | -0.2213772004 |
| GSE28863_A2 | Down | -0.1371611587 |
| GSE28863_A3 | Down | -0.2222644126 |
| GSE28863_A4 | Down | -0.1077839507 |
| GSE48662 | Down | -0.1679880322 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-373-3p | MIMAT0000726 | MIRT002506 | Microarray//Microarray;Other | Functional MTI (Weak) | 15685193 |
| hsa-miR-148b-3p | MIMAT0000759 | MIRT019284 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-365a-3p | MIMAT0000710 | MIRT044028 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-28-5p | MIMAT0000085 | MIRT050001 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-373-3p | MIMAT0000726 | NA | hsa-miR-373 | 15685193 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
