HCSGD entry for SENP2
1. General information
| Official gene symbol | SENP2 |
|---|---|
| Entrez ID | 59343 |
| Gene full name | SUMO1/sentrin/SMT3 specific peptidase 2 |
| Other gene symbols | AXAM2 SMT3IP2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001934 | Positive regulation of protein phosphorylation | IEA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005643 | Nuclear pore | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0007507 | Heart development | IEA | biological_process |
| GO:0008234 | Cysteine-type peptidase activity | IEA | molecular_function |
| GO:0009950 | Dorsal/ventral axis specification | IEA | biological_process |
| GO:0015031 | Protein transport | IEA | biological_process |
| GO:0016055 | Wnt signaling pathway | IEA | biological_process |
| GO:0016605 | PML body | IEA ISS | cellular_component |
| GO:0016925 | Protein sumoylation | TAS | biological_process |
| GO:0016926 | Protein desumoylation | IEA ISS | biological_process |
| GO:0016929 | SUMO-specific protease activity | IDA | molecular_function |
| GO:0019904 | Protein domain specific binding | IEA | molecular_function |
| GO:0030111 | Regulation of Wnt signaling pathway | NAS | biological_process |
| GO:0031965 | Nuclear membrane | IEA | cellular_component |
| GO:0032091 | Negative regulation of protein binding | IEA | biological_process |
| GO:0032875 | Regulation of DNA endoreduplication | IEA | biological_process |
| GO:0035562 | Negative regulation of chromatin binding | IEA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0051028 | MRNA transport | IEA | biological_process |
| GO:0060707 | Trophoblast giant cell differentiation | IEA | biological_process |
| GO:0060711 | Labyrinthine layer development | IEA | biological_process |
| GO:0060712 | Spongiotrophoblast layer development | IEA | biological_process |
| GO:2000045 | Regulation of G1/S transition of mitotic cell cycle | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5747465294 | 0.2682918696 | 0.9999902473 | 0.9912563588 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0028973794 |
| GSE13712_SHEAR | Down | -0.0882057714 |
| GSE13712_STATIC | Down | -0.0877123123 |
| GSE19018 | Down | -0.1025486751 |
| GSE19899_A1 | Down | -0.1565222513 |
| GSE19899_A2 | Down | -0.4307815262 |
| PubMed_21979375_A1 | Down | -1.0835873878 |
| PubMed_21979375_A2 | Down | -0.0544915607 |
| GSE35957 | Up | 0.0291528473 |
| GSE36640 | Up | 0.3232571221 |
| GSE54402 | Down | -0.1577412140 |
| GSE9593 | Up | 0.0917839306 |
| GSE43922 | Down | -0.0052417095 |
| GSE24585 | Up | 0.3683450674 |
| GSE37065 | Up | 0.2856249141 |
| GSE28863_A1 | Up | 0.4271640583 |
| GSE28863_A2 | Up | 0.6415194416 |
| GSE28863_A3 | Down | -0.1048545743 |
| GSE28863_A4 | Down | -0.2120653657 |
| GSE48662 | Down | -0.3763423788 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-98-5p | MIMAT0000096 | MIRT027689 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-30d-5p | MIMAT0000245 | MIRT047781 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21811608 | In addition Tpr depletion impacts on level and function of the SUMO-protease SENP2 thus affecting SUMOylation regulation at the nuclear pore and overall SUMOylation in the cell |
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