HCSGD entry for TRPV4

1. General information

Official gene symbolTRPV4
Entrez ID59341
Gene full nametransient receptor potential cation channel, subfamily V, member 4
Other gene symbolsCMT2C HMSN2C OTRPC4 SMAL SPSMA SSQTL1 TRP12 VRL2 VROAC
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003779Actin bindingISSmolecular_function
GO:0005034Osmosensor activityIEAmolecular_function
GO:0005080Protein kinase C bindingIEA ISSmolecular_function
GO:0005261Cation channel activityIDAmolecular_function
GO:0005262Calcium channel activityIDA IEAmolecular_function
GO:0005516Calmodulin bindingIMPmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005881Cytoplasmic microtubuleIEA ISScellular_component
GO:0005886Plasma membraneIDA ISScellular_component
GO:0005912Adherens junctionISScellular_component
GO:0005925Focal adhesionIEA ISScellular_component
GO:0005929CiliumIEAcellular_component
GO:0006816Calcium ion transportIDA NASbiological_process
GO:0006874Cellular calcium ion homeostasisIDAbiological_process
GO:0006884Cell volume homeostasisTASbiological_process
GO:0007015Actin filament organizationIEA ISSbiological_process
GO:0007043Cell-cell junction assemblyIEA ISSbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationIDA IEAbiological_process
GO:0007231Osmosensory signaling pathwayIEA ISS TASbiological_process
GO:0008017Microtubule bindingIEA ISSmolecular_function
GO:0008219Cell deathIEAbiological_process
GO:0009612Response to mechanical stimulusTASbiological_process
GO:0009986Cell surfaceIEAcellular_component
GO:0010977Negative regulation of neuron projection developmentIEA ISSbiological_process
GO:0016021Integral component of membraneIEA NAScellular_component
GO:0019901Protein kinase bindingIPImolecular_function
GO:0030027LamellipodiumIEA ISScellular_component
GO:0030103Vasopressin secretionIEAbiological_process
GO:0030175FilopodiumIEA ISScellular_component
GO:0030426Growth coneIEA ISScellular_component
GO:0030864Cortical actin cytoskeletonIEA ISScellular_component
GO:0031117Positive regulation of microtubule depolymerizationIEA ISSbiological_process
GO:0031410Cytoplasmic vesicleIEAcellular_component
GO:0031532Actin cytoskeleton reorganizationIEA ISSbiological_process
GO:0032587Ruffle membraneIEA ISScellular_component
GO:0034605Cellular response to heatIEA ISSbiological_process
GO:0042169SH2 domain bindingIEA ISSmolecular_function
GO:0042538Hyperosmotic salinity responseIEAbiological_process
GO:0043014Alpha-tubulin bindingIEA ISSmolecular_function
GO:0043622Cortical microtubule organizationIEA ISSbiological_process
GO:0046785Microtubule polymerizationIEA ISSbiological_process
GO:0047484Regulation of response to osmotic stressIEAbiological_process
GO:0048487Beta-tubulin bindingIEA ISSmolecular_function
GO:0051015Actin filament bindingIEA ISSmolecular_function
GO:0070509Calcium ion importIEA ISSbiological_process
GO:0071470Cellular response to osmotic stressISSbiological_process
GO:0071476Cellular hypotonic responseIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.11915184830.87699058930.70762540611.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0779355121
GSE13712_SHEARUp0.8921352439
GSE13712_STATICUp1.0598710145
GSE19018Up0.2388063592
GSE19899_A1Up0.0161435970
GSE19899_A2Down-0.0037438986
PubMed_21979375_A1Down-0.3974165918
PubMed_21979375_A2Down-0.2637630761
GSE35957Up0.0447179360
GSE36640Down-0.0713806913
GSE54402Down-0.1107514751
GSE9593Up0.3290537968
GSE43922Up0.0484698892
GSE24585Up0.2180695132
GSE37065Up0.2176588660
GSE28863_A1Up0.1062451712
GSE28863_A2Up0.0761973935
GSE28863_A3Up0.3521355280
GSE28863_A4Down-0.0287752382
GSE48662Up0.1979843015

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018474MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.