HCSGD entry for RBBP8
1. General information
| Official gene symbol | RBBP8 |
|---|---|
| Entrez ID | 5932 |
| Gene full name | retinoblastoma binding protein 8 |
| Other gene symbols | COM1 CTIP JWDS RIM SAE2 SCKL2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000014 | Single-stranded DNA endodeoxyribonuclease activity | IMP | molecular_function |
| GO:0000075 | Cell cycle checkpoint | TAS | biological_process |
| GO:0000082 | G1/S transition of mitotic cell cycle | IEA | biological_process |
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0000724 | Double-strand break repair via homologous recombination | IDA | biological_process |
| GO:0000737 | DNA catabolic process, endonucleolytic | IMP | biological_process |
| GO:0001103 | RNA polymerase II repressing transcription factor binding | IPI | molecular_function |
| GO:0001106 | RNA polymerase II transcription corepressor activity | IDA | molecular_function |
| GO:0001835 | Blastocyst hatching | IEA | biological_process |
| GO:0003684 | Damaged DNA binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | TAS | cellular_component |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006366 | Transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0007126 | Meiosis | IEA | biological_process |
| GO:0010792 | DNA double-strand break processing involved in repair via single-strand annealing | IMP | biological_process |
| GO:0017053 | Transcriptional repressor complex | IDA | cellular_component |
| GO:0031572 | G2 DNA damage checkpoint | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9353902321 | 0.0075918088 | 0.9999902473 | 0.1742144725 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0403381033 |
| GSE13712_SHEAR | Down | -0.0344276717 |
| GSE13712_STATIC | Down | -0.1786716308 |
| GSE19018 | Down | -0.8392794308 |
| GSE19899_A1 | Down | -1.3039079737 |
| GSE19899_A2 | Down | -0.8547960450 |
| PubMed_21979375_A1 | Down | -0.1066443100 |
| PubMed_21979375_A2 | Down | -1.1587936058 |
| GSE35957 | Down | -0.4246435901 |
| GSE36640 | Down | -2.1575642055 |
| GSE54402 | Down | -0.1650975158 |
| GSE9593 | Down | -0.3839523077 |
| GSE43922 | Down | -0.0919989294 |
| GSE24585 | Down | -0.3290905126 |
| GSE37065 | Down | -0.0622730278 |
| GSE28863_A1 | Up | 0.1443953395 |
| GSE28863_A2 | Up | 0.1791582785 |
| GSE28863_A3 | Up | 0.2615395666 |
| GSE28863_A4 | Up | 0.0616101380 |
| GSE48662 | Down | -0.4130071092 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT019821 | Microarray | Functional MTI (Weak) | 20215506 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25582120 | BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres |
| 25582120 | Here, we show that the tumour suppressor BRCA1, together with its interacting partner CtIP, both acting in end resection, also promotes end-joining of uncapped telomeres |
| 25582120 | BRCA1 and CtIP do not function in the ATM-dependent telomere damage signalling, nor in telomere overhang removal, which are critical for telomere fusions by C-NHEJ |
| 25582120 | Instead, BRCA1 and CtIP act in the same pathway as LIG3 to promote joining of de-protected telomeres by A-NHEJ |
| 25582120 | Our work therefore ascribes novel roles for BRCA1 and CtIP in end-processing and fusion reactions at uncapped telomeres, underlining the complexity of DNA repair pathways that act at chromosome ends lacking protective structures |
| 22704488 | In this report, we found that Nampt physically associated with CtIP and DNA-PKcs/Ku80, which are key factors in HR and NHEJ, respectively |
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