HCSGD entry for BCKDHA
1. General information
| Official gene symbol | BCKDHA |
|---|---|
| Entrez ID | 593 |
| Gene full name | branched chain keto acid dehydrogenase E1, alpha polypeptide |
| Other gene symbols | BCKDE1A MSU MSUD1 OVD1A |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003826 | Alpha-ketoacid dehydrogenase activity | IDA | molecular_function |
| GO:0003863 | 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005739 | Mitochondrion | TAS | cellular_component |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0005947 | Mitochondrial alpha-ketoglutarate dehydrogenase complex | IDA | cellular_component |
| GO:0009083 | Branched-chain amino acid catabolic process | IDA TAS | biological_process |
| GO:0016624 | Oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor | IEA | molecular_function |
| GO:0016831 | Carboxy-lyase activity | TAS | molecular_function |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7863337905 | 0.1231000684 | 0.9999902473 | 0.6743219355 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4711699432 |
| GSE13712_SHEAR | Down | -0.8512473417 |
| GSE13712_STATIC | Down | -0.3031884218 |
| GSE19018 | Up | 0.0636832292 |
| GSE19899_A1 | Down | -0.1394929738 |
| GSE19899_A2 | Up | 0.6368712996 |
| PubMed_21979375_A1 | Up | 0.5104539235 |
| PubMed_21979375_A2 | Up | 0.2155986525 |
| GSE35957 | Down | -0.5759096856 |
| GSE36640 | Down | -0.6490811020 |
| GSE54402 | Up | 0.2545787004 |
| GSE9593 | Down | -0.3439267642 |
| GSE43922 | Up | 0.0465261793 |
| GSE24585 | Up | 0.0868433014 |
| GSE37065 | Down | -0.0053116733 |
| GSE28863_A1 | Up | 0.1569663985 |
| GSE28863_A2 | Up | 0.0258266278 |
| GSE28863_A3 | Down | -0.1273104707 |
| GSE28863_A4 | Down | -0.1433515764 |
| GSE48662 | Down | -0.0459383836 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041443 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-29c-3p | MIMAT0000681 | MIRT044243 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
