HCSGD entry for RBBP5
1. General information
| Official gene symbol | RBBP5 |
|---|---|
| Entrez ID | 5929 |
| Gene full name | retinoblastoma binding protein 5 |
| Other gene symbols | RBQ3 SWD1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IDA | biological_process |
| GO:0018022 | Peptidyl-lysine methylation | IDA | biological_process |
| GO:0035064 | Methylated histone residue binding | IDA | molecular_function |
| GO:0035097 | Histone methyltransferase complex | IDA IPI | cellular_component |
| GO:0042800 | Histone methyltransferase activity (H3-K4 specific) | IDA | molecular_function |
| GO:0043627 | Response to estrogen | IDA | biological_process |
| GO:0044212 | Transcription regulatory region DNA binding | IDA | molecular_function |
| GO:0048188 | Set1C/COMPASS complex | IDA | cellular_component |
| GO:0051568 | Histone H3-K4 methylation | IDA | biological_process |
| GO:0071339 | MLL1 complex | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4774789750 | 0.1503849854 | 0.9999902473 | 0.7498168593 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2668443003 |
| GSE13712_SHEAR | Up | 0.0498460892 |
| GSE13712_STATIC | Down | -0.4359561173 |
| GSE19018 | Down | -0.1475615603 |
| GSE19899_A1 | Down | -0.1402329513 |
| GSE19899_A2 | Down | -0.1418325655 |
| PubMed_21979375_A1 | Up | 0.4012357341 |
| PubMed_21979375_A2 | Down | -0.1242212902 |
| GSE35957 | Down | -0.5156439555 |
| GSE36640 | Down | -0.4413154604 |
| GSE54402 | Up | 0.1502270804 |
| GSE9593 | Down | -0.3185754599 |
| GSE43922 | Up | 0.1780338920 |
| GSE24585 | Up | 0.1922053087 |
| GSE37065 | Up | 0.0363206846 |
| GSE28863_A1 | Down | -0.0984427040 |
| GSE28863_A2 | Up | 0.4139654450 |
| GSE28863_A3 | Down | -0.6357504505 |
| GSE28863_A4 | Down | -0.1988811458 |
| GSE48662 | Up | 0.0757008356 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016367 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-128-3p | MIMAT0000424 | MIRT021974 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-122-5p | MIMAT0000421 | MIRT023318 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-1 | MIMAT0000416 | MIRT023722 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040532 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 19208841 | H3K4 methyltransferase MLL1 directly binds to and is required, along with its core component RbBP5, for the induction of p16 by oncogenic Ras |
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