HCSGD entry for RBBP4
1. General information
| Official gene symbol | RBBP4 |
|---|---|
| Entrez ID | 5928 |
| Gene full name | retinoblastoma binding protein 4 |
| Other gene symbols | NURF55 RBAP48 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006200 | ATP catabolic process | IDA | biological_process |
| GO:0006260 | DNA replication | IEA | biological_process |
| GO:0006334 | Nucleosome assembly | TAS | biological_process |
| GO:0006338 | Chromatin remodeling | IDA | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0008094 | DNA-dependent ATPase activity | IDA | molecular_function |
| GO:0008285 | Negative regulation of cell proliferation | TAS | biological_process |
| GO:0016580 | Sin3 complex | NAS | cellular_component |
| GO:0016581 | NuRD complex | IDA IEA NAS | cellular_component |
| GO:0016589 | NURF complex | IDA | cellular_component |
| GO:0031497 | Chromatin assembly | IDA | biological_process |
| GO:0033186 | CAF-1 complex | IDA | cellular_component |
| GO:0034080 | CENP-A containing nucleosome assembly at centromere | TAS | biological_process |
| GO:0035098 | ESC/E(Z) complex | IDA IEA | cellular_component |
| GO:0042393 | Histone binding | NAS | molecular_function |
| GO:0042826 | Histone deacetylase binding | IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9633162836 | 0.0073140230 | 0.9999902473 | 0.1711221333 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0387712931 |
| GSE13712_SHEAR | Up | 0.0846842031 |
| GSE13712_STATIC | Down | -0.2228756715 |
| GSE19018 | Down | -0.4125963615 |
| GSE19899_A1 | Down | -0.1545399026 |
| GSE19899_A2 | Down | -1.0062536610 |
| PubMed_21979375_A1 | Down | -0.6144324085 |
| PubMed_21979375_A2 | Down | -0.4026975801 |
| GSE35957 | Down | -0.3926325050 |
| GSE36640 | Down | -0.9662138238 |
| GSE54402 | Down | -0.0763364429 |
| GSE9593 | Down | -0.4290123412 |
| GSE43922 | Down | -0.3577508641 |
| GSE24585 | Up | 0.1398105448 |
| GSE37065 | Down | -0.0586872895 |
| GSE28863_A1 | Up | 0.4919792996 |
| GSE28863_A2 | Up | 0.1574809856 |
| GSE28863_A3 | Down | -1.0328311865 |
| GSE28863_A4 | Down | -0.6221437511 |
| GSE48662 | Up | 0.0737132251 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040854 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-3p | MIMAT0001340 | MIRT042541 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043073 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051653 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26491019 | Here, we demonstrated that retinoblastoma-binding protein 4 (RBBP4) functions as a novel regulatory factor to increase the efficiency of importin alpha/beta-mediated nuclear import |
| 26491019 | RBBP4 accelerates the release of importin beta1 from importin alpha via competitive binding to the importin beta-binding domain of importin alpha in the presence of RanGTP |
| 26491019 | We showed that the importin alpha/beta pathway is down-regulated in replicative senescent cells, concomitant with a decrease in RBBP4 level |
| 26491019 | Knockdown of RBBP4 caused both suppression of nuclear transport and induction of cellular senescence |
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