HCSGD entry for RARRES3
1. General information
| Official gene symbol | RARRES3 |
|---|---|
| Entrez ID | 5920 |
| Gene full name | retinoic acid receptor responder (tazarotene induced) 3 |
| Other gene symbols | HRASLS4 HRSL4 PLA1/2-3 RIG1 TIG3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004623 | Phospholipase A2 activity | IDA | molecular_function |
| GO:0006644 | Phospholipid metabolic process | IDA | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016042 | Lipid catabolic process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0732245507 | 0.2081680901 | 0.5760942721 | 0.8832194973 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2026315499 |
| GSE13712_SHEAR | Down | -0.2774743882 |
| GSE13712_STATIC | Up | 0.8626338029 |
| GSE19018 | Down | -0.1491044824 |
| GSE19899_A1 | Down | -0.0102226654 |
| GSE19899_A2 | Down | -0.3884622469 |
| PubMed_21979375_A1 | Down | -0.4964953730 |
| PubMed_21979375_A2 | Down | -0.1238370598 |
| GSE35957 | Down | -2.0369484240 |
| GSE36640 | Up | 1.2608882348 |
| GSE54402 | Down | -0.0766631614 |
| GSE9593 | Up | 0.6862524257 |
| GSE43922 | Down | -0.0844396686 |
| GSE24585 | Up | 0.1101821899 |
| GSE37065 | Up | 1.0059412590 |
| GSE28863_A1 | Up | 0.2474643575 |
| GSE28863_A2 | Up | 0.5000253677 |
| GSE28863_A3 | Down | -0.0722651216 |
| GSE28863_A4 | Up | 0.0469550893 |
| GSE48662 | Up | 0.2913797263 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 8 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22374671 | We searched for STAT3-downstream molecule(s) responsible for the senescence-inducing activity in the supernatants of stimulated TIG3 and identified IGFBP5 as a major STAT3 mediator, because IGFBP5 was expressed from the early phase through the entire senescence process and was responsible for IL6/STAT3-induced ROS increase and premature senescence |
| 19696787 | To identify microRNAs (miRNAs) involved in oncogene-induced senescence, we examined the expression of miRNAs in primary human TIG3 fibroblasts after constitutive activation of B-RAF |
| 9548301 | Cellular proteins of a normal human diploid fibroblast line (TIG-3) at various stages of replicative aging were resolved by horizontal isoelectric focusing on an immobilized pH gradient, followed by vertical sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis (PAGE) |
| 8569279 | This was also true in other human diploid fibroblast lines, TIG-3 and MRC-5 |
| 8294468 | Three complete cDNA clones encoding Id-related helix-loop-helix (HLH) proteins lacking a basic region were isolated from a pcD2 cDNA expression library prepared from TIG-3 human diploid fibroblasts (HDF) |
| 1614223 | The migration of human fetal lung fibroblasts (TIG-1 and TIG-3) decreased only very slightly with increasing passage, whereas the migration of human fetal skin fibroblasts (TIG-3S) declined gradually: the difference in cell migratory ability between early and late passages was significant (P less than 0 |
| 1722008 | The electrophoretic mobility of 13 human diploid cell strains, TIG-1, TIG-2, TIG-3, TIG-7, WI-38, IMR-90, MRC-5, MRC-9, TIG-1H, TIG-1L, TIG-2M, TIG-2B, and TIG-3S, which were established from different tissues of human embryos, was studied at different passages |
| 7053395 | The DNA content of single nuclei in confluent cultures of aging human embryonic fibroblasts, TIG-3, was measured by means of flow cytofluorometry |
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