HCSGD entry for RAP2A
1. General information
| Official gene symbol | RAP2A |
|---|---|
| Entrez ID | 5911 |
| Gene full name | RAP2A, member of RAS oncogene family |
| Other gene symbols | K-REV KREV RAP2 RbBP-30 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003924 | GTPase activity | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0007264 | Small GTPase mediated signal transduction | IEA | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0030336 | Negative regulation of cell migration | IEA | biological_process |
| GO:0030496 | Midbody | IEA | cellular_component |
| GO:0031532 | Actin cytoskeleton reorganization | IDA | biological_process |
| GO:0031954 | Positive regulation of protein autophosphorylation | IDA | biological_process |
| GO:0032486 | Rap protein signal transduction | ISS | biological_process |
| GO:0034613 | Cellular protein localization | IDA | biological_process |
| GO:0045184 | Establishment of protein localization | IDA | biological_process |
| GO:0046328 | Regulation of JNK cascade | IDA | biological_process |
| GO:0048814 | Regulation of dendrite morphogenesis | IDA | biological_process |
| GO:0055037 | Recycling endosome | IDA | cellular_component |
| GO:0055038 | Recycling endosome membrane | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3812262870 | 0.1438677558 | 0.9999902473 | 0.7307314104 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1805559438 |
| GSE13712_SHEAR | Down | -0.0488036233 |
| GSE13712_STATIC | Down | -0.1967951905 |
| GSE19018 | Up | 0.1128595281 |
| GSE19899_A1 | Up | 0.2484922817 |
| GSE19899_A2 | Down | -0.0729933212 |
| PubMed_21979375_A1 | Up | 0.4895909869 |
| PubMed_21979375_A2 | Up | 0.2001232064 |
| GSE35957 | Up | 0.0321328986 |
| GSE36640 | Down | -0.1965979561 |
| GSE54402 | Up | 0.3860187535 |
| GSE9593 | Down | -0.3924020193 |
| GSE43922 | Up | 0.2684400535 |
| GSE24585 | Down | -0.5558011715 |
| GSE37065 | Down | -0.1343033382 |
| GSE28863_A1 | Down | -0.0263689645 |
| GSE28863_A2 | Up | 0.1019268209 |
| GSE28863_A3 | Down | -0.8544381067 |
| GSE28863_A4 | Up | 0.2607660873 |
| GSE48662 | Down | -0.6308352141 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Guanosine-5'-Triphosphate | DB04137 | EXPT01660 |
| Guanosine-5'-Diphosphate | DB04315 | EXPT01573 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | MIRT047381 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
