HCSGD entry for RAP1GAP
1. General information
| Official gene symbol | RAP1GAP |
|---|---|
| Entrez ID | 5909 |
| Gene full name | RAP1 GTPase activating protein |
| Other gene symbols | RAP1GA1 RAP1GAP1 RAP1GAPII RAPGAP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | cellular_component |
| GO:0003924 | GTPase activity | NAS | molecular_function |
| GO:0005096 | GTPase activator activity | IEA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005829 | Cytosol | IDA TAS | cellular_component |
| GO:0006184 | GTP catabolic process | NAS | biological_process |
| GO:0007165 | Signal transduction | NAS | biological_process |
| GO:0008152 | Metabolic process | NAS | biological_process |
| GO:0016020 | Membrane | IDA | cellular_component |
| GO:0017016 | Ras GTPase binding | IPI | molecular_function |
| GO:0030695 | GTPase regulator activity | IEA | molecular_function |
| GO:0032318 | Regulation of Ras GTPase activity | IDA | biological_process |
| GO:0032854 | Positive regulation of Rap GTPase activity | IDA | biological_process |
| GO:0042803 | Protein homodimerization activity | IPI | molecular_function |
| GO:0046582 | Rap GTPase activator activity | IDA | molecular_function |
| GO:0051056 | Regulation of small GTPase mediated signal transduction | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3682070552 | 0.9469231526 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0447875031 |
| GSE13712_SHEAR | Down | -0.0672659620 |
| GSE13712_STATIC | Up | 0.0485452543 |
| GSE19018 | Up | 0.0364188199 |
| GSE19899_A1 | Down | -0.0535647646 |
| GSE19899_A2 | Up | 0.2850616810 |
| PubMed_21979375_A1 | Up | 0.0452694090 |
| PubMed_21979375_A2 | Up | 0.0349291889 |
| GSE35957 | Up | 0.0830462317 |
| GSE36640 | Up | 0.1237512204 |
| GSE54402 | Up | 0.4823088978 |
| GSE9593 | Up | 0.0098168721 |
| GSE43922 | Up | 0.0558276342 |
| GSE24585 | Up | 0.0345077833 |
| GSE37065 | Down | -0.0197368053 |
| GSE28863_A1 | Down | -0.0532445916 |
| GSE28863_A2 | Up | 0.1573030956 |
| GSE28863_A3 | Up | 0.2029794540 |
| GSE28863_A4 | Up | 0.1798464580 |
| GSE48662 | Up | 0.0312913417 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024590 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026546 | Microarray | Functional MTI (Weak) | 19074876 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
