HCSGD entry for IL21

1. General information

Official gene symbolIL21
Entrez ID59067
Gene full nameinterleukin 21
Other gene symbolsIL-21 Za11
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002729Positive regulation of natural killer cell cytokine productionIEAbiological_process
GO:0005125Cytokine activityIEAmolecular_function
GO:0005126Cytokine receptor bindingTASmolecular_function
GO:0005134Interleukin-2 receptor bindingIPImolecular_function
GO:0005615Extracellular spaceNAScellular_component
GO:0006955Immune responseIEAbiological_process
GO:0007165Signal transductionNASbiological_process
GO:0008284Positive regulation of cell proliferationIDAbiological_process
GO:0030890Positive regulation of B cell proliferationIDAbiological_process
GO:0032733Positive regulation of interleukin-10 productionIEAbiological_process
GO:0032740Positive regulation of interleukin-17 productionIDAbiological_process
GO:0032825Positive regulation of natural killer cell differentiationIEAbiological_process
GO:0034105Positive regulation of tissue remodelingICbiological_process
GO:0042102Positive regulation of T cell proliferationIDAbiological_process
GO:0042511Positive regulation of tyrosine phosphorylation of Stat1 proteinIDAbiological_process
GO:0042517Positive regulation of tyrosine phosphorylation of Stat3 proteinIDAbiological_process
GO:0045078Positive regulation of interferon-gamma biosynthetic processNASbiological_process
GO:0045954Positive regulation of natural killer cell mediated cytotoxicityIEAbiological_process
GO:0048469Cell maturationIDAbiological_process
GO:0050729Positive regulation of inflammatory responseICbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.52742910220.81037394100.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1076228105
GSE13712_SHEARDown-0.2174499385
GSE13712_STATICUp0.0109060580
GSE19018Down-0.0249508352
GSE19899_A1Up0.0481714352
GSE19899_A2Up0.3519594127
PubMed_21979375_A1Up0.0071847053
PubMed_21979375_A2Down-0.1318996480
GSE35957Up0.1789908322
GSE36640Up0.0633321183
GSE54402Up0.1230049483
GSE9593Up0.1513004819
GSE43922Up0.0149820456
GSE24585Up0.1801868863
GSE37065Down-0.0014371641
GSE28863_A1Up0.0112295758
GSE28863_A2Down-0.1722812286
GSE28863_A3Up0.1779728538
GSE28863_A4Down-0.0774703023
GSE48662Up0.0402776095

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.