HCSGD entry for RAN
1. General information
| Official gene symbol | RAN |
|---|---|
| Entrez ID | 5901 |
| Gene full name | RAN, member RAS oncogene family |
| Other gene symbols | ARA24 Gsp1 TC4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000785 | Chromatin | IDA | cellular_component |
| GO:0003682 | Chromatin binding | TAS | molecular_function |
| GO:0003713 | Transcription coactivator activity | NAS | molecular_function |
| GO:0003924 | GTPase activity | IEA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005525 | GTP binding | IDA IEA | molecular_function |
| GO:0005643 | Nuclear pore | NAS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006259 | DNA metabolic process | TAS | biological_process |
| GO:0006611 | Protein export from nucleus | IDA | biological_process |
| GO:0006886 | Intracellular protein transport | IEA | biological_process |
| GO:0006913 | Nucleocytoplasmic transport | IEA | biological_process |
| GO:0007052 | Mitotic spindle organization | TAS | biological_process |
| GO:0007067 | Mitosis | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007264 | Small GTPase mediated signal transduction | IEA | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016032 | Viral process | TAS | biological_process |
| GO:0019058 | Viral life cycle | TAS | biological_process |
| GO:0030521 | Androgen receptor signaling pathway | NAS | biological_process |
| GO:0032092 | Positive regulation of protein binding | IDA | biological_process |
| GO:0042470 | Melanosome | IEA | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | NAS | biological_process |
| GO:0050681 | Androgen receptor binding | NAS | molecular_function |
| GO:0075733 | Intracellular transport of virus | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8973937578 | 0.0794608981 | 0.9999902473 | 0.5324567974 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1274707218 |
| GSE13712_SHEAR | Up | 0.0509086584 |
| GSE13712_STATIC | Up | 0.0210182654 |
| GSE19018 | Down | -0.6105588575 |
| GSE19899_A1 | Down | -0.1004457146 |
| GSE19899_A2 | Down | -0.1250938162 |
| PubMed_21979375_A1 | Up | 0.2729450310 |
| PubMed_21979375_A2 | Down | -0.2693185625 |
| GSE35957 | Down | -0.2528487457 |
| GSE36640 | Down | -0.3570755544 |
| GSE54402 | Down | -0.0053503001 |
| GSE9593 | Up | 0.0713930705 |
| GSE43922 | Down | -0.0368305860 |
| GSE24585 | Down | -0.2756796712 |
| GSE37065 | Down | -0.0771666989 |
| GSE28863_A1 | Up | 0.0333598280 |
| GSE28863_A2 | Up | 0.3511190617 |
| GSE28863_A3 | Down | -0.0128314837 |
| GSE28863_A4 | Down | -0.0527101438 |
| GSE48662 | Down | -0.5872383204 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Guanosine-5'-Diphosphate | DB04315 | EXPT01573 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-29a-3p | MIMAT0000086 | MIRT001196 | flow//qRT-PCR//GFP reporter assay | Non-Functional MTI | 19818597 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT021084 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT021084 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1250-5p | MIMAT0005902 | MIRT035863 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037549 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-31-3p | MIMAT0004504 | MIRT038929 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-22-5p | MIMAT0004495 | MIRT038960 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040262 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040590 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-500a-3p | MIMAT0002871 | MIRT041154 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-339-5p | MIMAT0000764 | MIRT042737 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044572 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045558 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051173 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1260b | MIMAT0015041 | MIRT052689 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23160023 | BACKGROUND: The small GTPase Ran, Ras-related nuclear protein, plays important roles in multiple fundamental cellular functions such as nucleocytoplasmic transport, mitotic spindle assembly, and nuclear envelope formation, by binding to either GTP or GDP as a molecular switch |
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