HCSGD entry for BCHE

1. General information

Official gene symbolBCHE
Entrez ID590
Gene full namebutyrylcholinesterase
Other gene symbolsCHE1 E1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001540Beta-amyloid bindingNASmolecular_function
GO:0003824Catalytic activityNASmolecular_function
GO:0003990Acetylcholinesterase activityIBA ISSmolecular_function
GO:0004104Cholinesterase activityIDA IEAmolecular_function
GO:0005576Extracellular regionNAS TAScellular_component
GO:0005615Extracellular spaceIBA IEAcellular_component
GO:0005641Nuclear envelope lumenIEAcellular_component
GO:0005788Endoplasmic reticulum lumenIBA IEAcellular_component
GO:0007271Synaptic transmission, cholinergicIBAbiological_process
GO:0007612LearningIEAbiological_process
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0014016Neuroblast differentiationIEAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0019695Choline metabolic processIBA IEAbiological_process
GO:0019899Enzyme bindingNASmolecular_function
GO:0033265Choline bindingIEAmolecular_function
GO:0042493Response to drugIEAbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0043279Response to alkaloidIEAbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0050783Cocaine metabolic processTASbiological_process
GO:0050805Negative regulation of synaptic transmissionIEAbiological_process
GO:0051384Response to glucocorticoidIEAbiological_process
GO:0051593Response to folic acidIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.47707792640.03444523380.99999024730.3511359411

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-1.0691070441
GSE13712_SHEARDown-1.4455556745
GSE13712_STATICDown-4.5535989603
GSE19018Down-0.0548801913
GSE19899_A1Up0.1749414924
GSE19899_A2Up0.5651345094
PubMed_21979375_A1Down-0.1123276957
PubMed_21979375_A2Down-0.3205196067
GSE35957Up1.5920846817
GSE36640Down-0.0638673002
GSE54402Down-0.1110742442
GSE9593Down-0.0240277732
GSE43922Up0.0122488330
GSE24585Up0.4179257306
GSE37065Down-0.0116249843
GSE28863_A1Down-0.0673159817
GSE28863_A2Up0.2207475204
GSE28863_A3Up0.1905755181
GSE28863_A4Down-0.0904029867
GSE48662Up0.0301288805

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

CholineDB00122 NUTR00020
TacrineDB00382 APRD00690
PyridostigmineDB00545 APRD00380
GalantamineDB00674 APRD00206 | EXPT01628
PralidoximeDB00733 APRD01193
HexafluroniumDB00941 APRD01013
DemecariumDB00944 APRD00905
RivastigmineDB00989 APRD00321
EdrophoniumDB01010 APRD00944
EchothiophateDB01057 APRD00942
MivacuriumDB01226 APRD01119
Diethylphosphono GroupDB02811 EXPT01161
Methylphosphinic AcidDB02845 EXPT02226 | DB04390
Butanoic AcidDB03568 EXPT00774
9-N-Phenylmethylamino-TacrineDB03672 EXPT00297
2-(N-Morpholino)-Ethanesulfonic AcidDB03814 EXPT02154
Ethyl Dihydrogen PhosphateDB03822 EXPT01327
ButyrylthiocholineDB04250 EXPT00639
Monoisopropyl Ester Phosphonic Acid GroupDB04251 EXPT02177
PhenserineDB04892 -
DODECANESULFONATE IONDB07681 -
9-(3-IODOBENZYLAMINO)-1,2,3,4-TETRAHYDROACRIDINEDB07940 -
(1R)-MENTHYL HEXYL PHOSPHONATE GROUPDB08200 -
(1S)-MENTHYL HEXYL PHOSPHONATE GROUPDB08201 -
ETHYL HYDROGEN DIETHYLAMIDOPHOSPHATEDB08658 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018332MicroarrayFunctional MTI (Weak)18185580
hsa-miR-26b-5pMIMAT0000083MIRT029814MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.