HCSGD entry for RAD52
1. General information
| Official gene symbol | RAD52 |
|---|---|
| Entrez ID | 5893 |
| Gene full name | RAD52 homolog (S. cerevisiae) |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000724 | Double-strand break repair via homologous recombination | IEA TAS | biological_process |
| GO:0000730 | DNA recombinase assembly | TAS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | TAS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006281 | DNA repair | IEA TAS | biological_process |
| GO:0006302 | Double-strand break repair | TAS | biological_process |
| GO:0006310 | DNA recombination | IEA | biological_process |
| GO:0006312 | Mitotic recombination | TAS | biological_process |
| GO:0007131 | Reciprocal meiotic recombination | TAS | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7176670415 | 0.5934312754 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0298374059 |
| GSE13712_SHEAR | Up | 0.4214339594 |
| GSE13712_STATIC | Up | 0.1373451036 |
| GSE19018 | Up | 0.0082641928 |
| GSE19899_A1 | Up | 0.1013996322 |
| GSE19899_A2 | Up | 0.0880456666 |
| PubMed_21979375_A1 | Down | -0.3525927540 |
| PubMed_21979375_A2 | Down | -0.2861522459 |
| GSE35957 | Down | -0.1390761730 |
| GSE36640 | Down | -0.0418061506 |
| GSE54402 | Down | -0.1657119634 |
| GSE9593 | Down | -0.0523364429 |
| GSE43922 | Up | 0.0508884580 |
| GSE24585 | Up | 0.0464788435 |
| GSE37065 | Up | 0.0414930206 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.0169582850 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-210-3p | MIMAT0000267 | MIRT000156 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 19141645 |
| hsa-miR-210-3p | MIMAT0000267 | MIRT000156 | immunoprecipitaion//qRT-PCR | Functional MTI (Weak) | 19826008 |
| hsa-miR-373-3p | MIMAT0000726 | MIRT003914 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 19141645 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 19380905 | Telomere maintenance and survival in saccharomyces cerevisiae in the absence of telomerase and RAD52 |
| 19380905 | In the Saccharomyces cerevisiae strain W303, telomerase-null populations bypass senescence and, unless EXO1 is also deleted, this survival is RAD52 dependent |
| 19380905 | If W303 strains lacking telomerase and RAD52 first underwent telomere elongation, rare colonies could then bypass senescence |
| 19380905 | We suggest that longer telomeres provide a more proficient substrate for a novel telomere maintenance mechanism that does not rely on telomerase, RAD52, or POL32 |
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