HCSGD entry for RAD21
1. General information
| Official gene symbol | RAD21 |
|---|---|
| Entrez ID | 5885 |
| Gene full name | RAD21 homolog (S. pombe) |
| Other gene symbols | CDLS4 HR21 HRAD21 MCD1 NXP1 SCC1 hHR21 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000775 | Chromosome, centromeric region | TAS | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005694 | Chromosome | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006302 | Double-strand break repair | TAS | biological_process |
| GO:0006310 | DNA recombination | TAS | biological_process |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0007059 | Chromosome segregation | IEA | biological_process |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0007131 | Reciprocal meiotic recombination | TAS | biological_process |
| GO:0008278 | Cohesin complex | TAS | cellular_component |
| GO:0034991 | Nuclear meiotic cohesin complex | IEA | cellular_component |
| GO:0071168 | Protein localization to chromatin | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8687762965 | 0.0287175905 | 0.9999902473 | 0.3221988936 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1675073318 |
| GSE13712_SHEAR | Down | -0.1368886949 |
| GSE13712_STATIC | Down | -0.4146685595 |
| GSE19018 | Up | 0.5423796213 |
| GSE19899_A1 | Down | -0.1968420293 |
| GSE19899_A2 | Down | -1.0345862151 |
| PubMed_21979375_A1 | Down | -0.8765861575 |
| PubMed_21979375_A2 | Down | -1.3668942347 |
| GSE35957 | Down | -0.3433209436 |
| GSE36640 | Down | -1.2287232652 |
| GSE54402 | Down | -0.1290155139 |
| GSE9593 | Down | -0.2248304116 |
| GSE43922 | Down | -0.4712332330 |
| GSE24585 | Up | 0.1474764785 |
| GSE37065 | Up | 0.0919882674 |
| GSE28863_A1 | Up | 0.0079707396 |
| GSE28863_A2 | Up | 0.2308600144 |
| GSE28863_A3 | Down | -0.1660404272 |
| GSE28863_A4 | Up | 0.2611593109 |
| GSE48662 | Up | 0.0193300504 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024779 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026196 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-191-5p | MIMAT0000440 | MIRT045808 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052491 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26529363 | Suppression of RAD21 Induces Senescence of MDA-MB-231 Human Breast Cancer Cells Through RB1 Pathway Activation Via c-Myc Downregulation |
| 26529363 | Importantly, we showed that knockdown of RAD21 resulted in the appearance of several senescent markers, including enhanced senescence-associated beta-galactosidase activity and heterochromatin focus formation, as well as elevated p21 protein levels and RB1 pathway activation |
| 26529363 | Further biochemical analyses revealed that RAD21 knockdown led to the downregulation of c-Myc and its targets, including CDK4, a negative regulator of RB1, and blockedRB1 phosphorylation (pRB1), and the RB1-mediated transcriptional repression of E2F |
| 26529363 | Moreover, c-Myc downregulation was partially mediated by proteasome-dependent degradation within promyelocytic leukemia (PML) nuclear bodies, which were found to be highly abundant during RAD21 knockdown-induced senescence |
| 26529363 | Exogenous c-Myc reconstitution rescued cells from RAD21 silencing-induced senescence |
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